Literature DB >> 15588101

Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates.

João P C Tomé1, Maria G P M S Neves, Augusto C Tomé, José A S Cavaleiro, Marina Soncin, Michela Magaraggia, Stefania Ferro, Giulio Jori.   

Abstract

Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.

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Year:  2004        PMID： 15588101     DOI： 10.1021/jm040802v

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  25 in total

Review 1.  Glycosylated Porphyrins, Phthalocyanines, and Other Porphyrinoids for Diagnostics and Therapeutics.

Authors:  Sunaina Singh; Amit Aggarwal; N V S Dinesh K Bhupathiraju; Gianluca Arianna; Kirran Tiwari; Charles Michael Drain
Journal:  Chem Rev       Date:  2015-08-28       Impact factor: 60.622

2.  Chitosan augments photodynamic inactivation of gram-positive and gram-negative bacteria.

Authors:  Tsuimin Tsai; Hsiung-Fei Chien; Tze-Hsien Wang; Ching-Tsan Huang; Yaw-Bee Ker; Chin-Tin Chen
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

Review 3.  Fluorinated porphyrinoids as efficient platforms for new photonic materials, sensors, and therapeutics.

Authors:  N V S Dinesh K Bhupathiraju; Waqar Rizvi; James D Batteas; Charles Michael Drain
Journal:  Org Biomol Chem       Date:  2016-01-14       Impact factor: 3.876

4.  Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation.

Authors:  George P Tegos; Masahiro Anbe; Changming Yang; Tatiana N Demidova; Minahil Satti; Pawel Mroz; Sumbul Janjua; Faten Gad; Michael R Hamblin
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

5.  meso-Tetra(pentafluorophenyl)porphyrin as an efficient platform for combinatorial synthesis and the selection of new photodynamic therapeutics using a cancer cell line.

Authors:  Diana Samaroo; Mikki Vinodu; Xin Chen; Charles Michael Drain
Journal:  J Comb Chem       Date:  2007-09-15

6.  Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus.

Authors:  Hüseyin Taslı; Ayse Akbıyık; Nermin Topaloğlu; Vildan Alptüzün; Sülünay Parlar
Journal:  J Microbiol       Date:  2018-10-24       Impact factor: 3.422

Review 7.  Phage therapy and photodynamic therapy: low environmental impact approaches to inactivate microorganisms in fish farming plants.

Authors:  Adelaide Almeida; Angela Cunha; Newton C M Gomes; Eliana Alves; Liliana Costa; Maria A F Faustino
Journal:  Mar Drugs       Date:  2009-07-30       Impact factor: 5.118

8.  Antimicrobial photodynamic therapy: study of bacterial recovery viability and potential development of resistance after treatment.

Authors:  Anabela Tavares; Carla M B Carvalho; Maria A Faustino; Maria G P M S Neves; João P C Tomé; Augusto C Tomé; José A S Cavaleiro; Angela Cunha; Newton C M Gomes; Eliana Alves; Adelaide Almeida
Journal:  Mar Drugs       Date:  2010-01-20       Impact factor: 5.118

9.  Chemical functionalization of bone implants with nanoparticle-stabilized chitosan and methotrexate for inhibiting both osteoclastoma formation and bacterial infection.

Authors:  Li-Hua Li; Mei Li; Dan Li; Peng He; Hong Xia; Yu Zhang; Chuanbin Mao
Journal:  J Mater Chem B       Date:  2014-09-28       Impact factor: 6.331

10.  Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.

Authors:  Maritza Barcia-Macay; Cristina Seral; Marie-Paule Mingeot-Leclercq; Paul M Tulkens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191
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