Literature DB >> 15588095

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.

Ariamala Gopalsamy1, Kitae Lim, Gregory Ciszewski, Kaapjoo Park, John W Ellingboe, Jonathan Bloom, Shabana Insaf, Janis Upeslacis, Tarek S Mansour, Girija Krishnamurthy, Murthy Damarla, Yelena Pyatski, Douglas Ho, Anita Y M Howe, Mark Orlowski, Boris Feld, John O'Connell.   

Abstract

A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.

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Year:  2004        PMID： 15588095     DOI： 10.1021/jm0401255

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  20 in total

1.  Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.

Authors:  Anita Y M Howe; Huiming Cheng; Ian Thompson; Srinivas K Chunduru; Steve Herrmann; John O'Connell; Atul Agarwal; Rajiv Chopra; Alfred M Del Vecchio
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

2.  Structure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients.

Authors:  Qing Yang; Yuyang Ding; Fengling Feng; Enxiang Pan; Xiaozhen Fan; Xiuchang Ma; Ling Chen; Junling Zhao; Caijun Sun
Journal:  Medchemcomm       Date:  2017-07-25       Impact factor: 3.597

3.  Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.

Authors:  Hongmei Mo; Liangjun Lu; Tami Pilot-Matias; Ron Pithawalla; Rubina Mondal; Sherie Masse; Tatyana Dekhtyar; Teresa Ng; Gennadiy Koev; Vincent Stoll; Kent D Stewart; John Pratt; Pam Donner; Todd Rockway; Clarence Maring; Akhteruzzaman Molla
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

4.  A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles.

Authors:  Matthew R Medeiros; Scott E Schaus; John A Porco
Journal:  Org Lett       Date:  2011-07-08       Impact factor: 6.005

5.  Synergy of small molecular inhibitors of hepatitis C virus replication directed at multiple viral targets.

Authors:  David L Wyles; Kelly A Kaihara; Florin Vaida; Robert T Schooley
Journal:  J Virol       Date:  2006-12-20       Impact factor: 5.103

Review 6.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

7.  Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.

Authors:  Frederik Pauwels; Wendy Mostmans; Ludo M M Quirynen; Liesbet van der Helm; Carlo W Boutton; Anne-Stéphanie Rueff; Erna Cleiren; Pierre Raboisson; Dominique Surleraux; Origène Nyanguile; Kenneth A Simmen
Journal:  J Virol       Date:  2007-04-25       Impact factor: 5.103

8.  Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.

Authors:  David L Wyles; Kelly A Kaihara; Robert T Schooley
Journal:  Antimicrob Agents Chemother       Date:  2008-03-10       Impact factor: 5.191

9.  Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034).

Authors:  Mike Flint; Stanley Mullen; Anne M Deatly; Wei Chen; Lynn Z Miller; Robert Ralston; Colin Broom; Emilio A Emini; Anita Y M Howe
Journal:  Antimicrob Agents Chemother       Date:  2008-10-20       Impact factor: 5.191

10.  Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.

Authors:  Tanaji T Talele; Payal Arora; Shridhar S Kulkarni; Maulik R Patel; Satyakam Singh; Maksim Chudayeu; Neerja Kaushik-Basu
Journal:  Bioorg Med Chem       Date:  2010-05-15       Impact factor: 3.641
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