| Literature DB >> 15587710 |
Hiroyuki Haraguchi1, Yasumasa Tanaka, Amal Kabbash, Toshihiro Fujioka, Takashi Ishizu, Akira Yagi.
Abstract
Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their structures were elucidated to be 3-3''linked-(2'-hydroxy-4-O-isoprenylchalcone)-(2'''-hydroxy-4''-O-isoprenyldihydrochalcone) (1), 2-methoxy-3-(1,1'-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one and 5-hydroxyflavanone. These compounds, and the hydrolysis product of 1, displayed competitive inhibitory properties against MAO-B which was more effective than MAO-A.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15587710 DOI： 10.1016/j.phytochem.2004.06.025
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072