Literature DB >> 15587590

Inhibition of both Trypanosoma brucei bloodstream form and related glycolytic enzymes by a new kolavic acid derivative isolated from Entada abyssinica.

B Nyasse1, I Ngantchou, E M Tchana, B Sonké, C Denier, C Fontaine.   

Abstract

A new kolavic acid derivative known from spectroscopic analyses as monomethyl ester-15-kolavic acid was isolated from the stem bark of Entada abyssinica, a plant traditionally used in West and East Africa for the management of sleeping sickness. The new derivative showed a strong and selective inhibitory activity on the GAPDH enzyme of Trypanosoma brucei with an IC50 value of 0.012 mM.

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Year:  2004        PMID： 15587590

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  5 in total

1.  Antimicrobial and antioxidant properties of methanol extract, fractions and compounds from the stem bark of Entada abyssinica Stend ex A. Satabie.

Authors:  Gerald N Teke; Paul K Lunga; Hippolyte K Wabo; Jules-Roger Kuiate; Gerard Vilarem; Geraldine Giacinti; Haruhisa Kikuchi; Yoshiteru Oshima
Journal:  BMC Complement Altern Med       Date:  2011-07-19       Impact factor: 3.659

2.  Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae).

Authors:  Jean P Dzoyem; Raduis Melong; Armelle T Tsamo; Alembert T Tchinda; Deccaux G W F Kapche; Bonaventure T Ngadjui; Lyndy J McGaw; Jacobus N Eloff
Journal:  BMC Res Notes       Date:  2017-03-06

3.  Exploring the Phytochemicals of Acacia melanoxylon R. Br.

Authors:  Diana Alves; Sidónio Duarte; Pedro Arsénio; Joana Gonçalves; Cecília M P Rodrigues; Ana Lourenço; Patrícia Máximo
Journal:  Plants (Basel)       Date:  2021-12-08

Review 4.  Kinases as druggable targets in trypanosomatid protozoan parasites.

Authors:  Christopher Merritt; Lisseth E Silva; Angela L Tanner; Kenneth Stuart; Michael P Pollastri
Journal:  Chem Rev       Date:  2014-10-07       Impact factor: 60.622

Review 5.  Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis.

Authors:  Conrad V Simoben; Fidele Ntie-Kang; Sergi H Akone; Wolfgang Sippl
Journal:  Nat Prod Bioprospect       Date:  2018-05-09
  5 in total

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