| Literature DB >> 15585281 |
S Berland1, O Delattre, S Borzeix, Y Catonné, E Lopez.
Abstract
Raw nacre implants persist even after 9 months of implantation into bone tissue in sheep. However the nacre surface undergoes a limited biodegradation process. Smooth-surfaced nacre implants were seen to become microporous after implantation. The results of these long-term, in vivo studies show that the overall process involves bone-resorbing cells, relies on a two-phase mechanism and may correspond to a regulation process. The rate of surface change depends on the bone implantation site and the nacre/bone interaction. The in vivo biodegradability of nacre is a highly variable parameter. The size and shape of the implanted nacre and the cellular environment of the implant are key factors in determining the biodegradation kinetics of the nacre in a living system.Entities:
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Year: 2005 PMID： 15585281 DOI： 10.1016/j.biomaterials.2004.07.019
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479