Literature DB >> 15585106

An HIV type 1 subtype A outbreak among injecting drug users in Kazakhstan.

Aleksei F Bobkov1, Elena V Kazennova, Anna L Sukhanova, Marina R Bobkova, Vadim V Pokrovsky, Victoria V Zeman, Natalia G Kovtunenko, Isidora B Erasilova.   

Abstract

Kazakhstan experienced the start of the HIV-1 outbreak among intravenous drug users (IDUs) in 1997. To characterize genetically HIV-1 strains circulating in this country, peripheral blood mononuclear cells (PBMCs) DNA samples (1999-2002) derived from HIV-infected IDUs and their sexual partners in Pavlodar (n = 19), Shymkent (n = 6), and Qaraghandy (n = 18) regions were analyzed by the gag/env heteroduplex mobility assay (HMA). The 366-bp proviral env gene fragments encoding the gp120 C2-V3 region obtained from 16 individuals were sequenced. The results of HMA revealed that all 43 HIV-1 strains studied belonged to gag/env subtype A. The nucleotide sequence analysis showed a marked genetic homogeneity with the mean genetic distance being 3.63 +/- 2.39 (range 0.00-12.13). The mean genetic distance between each sequence within the Kazakhstan set and the East-European IDU subtype A consensus was 2.94 +/- 1.92 (range 0.79-8.48). The data presented thus confirm the spreading of the same IDU subtype A virus in the former Soviet Union.

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Year:  2004        PMID： 15585106     DOI： 10.1089/aid.2004.20.1134

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  12 in total

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Journal:  J Clin Microbiol       Date:  2015-02-18       Impact factor: 5.948

4.  HIV-1 genetic variants in the Russian Far East.

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5.  Short communication: molecular epidemiology of HIV type 1 infection in Kazakhstan: CRF02_AG prevalence is increasing in the southeastern provinces.

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Review 7.  Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia.

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Journal:  BMC Infect Dis       Date:  2006-11-14       Impact factor: 3.090

10.  Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries.

Authors:  Lazzat Aibekova; Brian Foley; Gonzalo Hortelano; Muhammad Raees; Sabit Abdraimov; Rakhmanbek Toichuev; Syed Ali
Journal:  PLoS One       Date:  2018-02-01       Impact factor: 3.240
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