| Literature DB >> 15583857 |
M Santoro1, F Carlomagno, R M Melillo, A Fusco.
Abstract
RET is the receptor for glial-derived neurotrophic factor growth factors. It is a paradigm of a single gene that causes different types of human cancer when targeted by different genetic alterations. Like other receptor tyrosine kinases, once activated, RET recruits a variety of signaling molecules that mediate biological responses. Here we review data on the signaling pathways that lead to RET-mediated cell transformation and recent evidence that manipulation of RET holds promise for thyroid cancer treatment.Entities:
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Year: 2004 PMID： 15583857 DOI： 10.1007/s00018-004-4276-8
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261