BACKGROUND: Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress. METHODS: Skh mice were exposed to carcinogenic doses of ultraviolet light (UV). The stressed group was subjected to the close proximity of fox urine as a source of stress from the presence of the odor of their natural predator, while the control group remained stress free. RESULTS: A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first tumor appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21. CONCLUSION: These results suggest that stress plays a role in potentiating cutaneous carcinogenesis.
BACKGROUND: Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress. METHODS: Skh mice were exposed to carcinogenic doses of ultraviolet light (UV). The stressed group was subjected to the close proximity of fox urine as a source of stress from the presence of the odor of their natural predator, while the control group remained stress free. RESULTS: A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first tumor appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21. CONCLUSION: These results suggest that stress plays a role in potentiating cutaneous carcinogenesis.
Authors: Oscar Vegas; Brian Poligone; Paul Blackcloud; Elaine S Gilmore; JoAnne VanBuskirk; Christopher T Ritchlin; Alice P Pentland; Scott A Walter; Yasmine Nousari; Francisco Tausk Journal: Brain Behav Immun Date: 2017-11-07 Impact factor: 7.217
Authors: Alison N Saul; Tatiana M Oberyszyn; Christine Daugherty; Donna Kusewitt; Susie Jones; Scott Jewell; William B Malarkey; Amy Lehman; Stanley Lemeshow; Firdaus S Dhabhar Journal: J Natl Cancer Inst Date: 2005-12-07 Impact factor: 13.506
Authors: Firdaus S Dhabhar; Alison N Saul; Christine Daugherty; Tyson H Holmes; Donna M Bouley; Tatiana M Oberyszyn Journal: Brain Behav Immun Date: 2009-09-16 Impact factor: 7.217
Authors: Marc S Weinberg; Aadra P Bhatt; Milena Girotti; Cher V Masini; Heidi E W Day; Serge Campeau; Robert L Spencer Journal: Endocrinology Date: 2008-10-09 Impact factor: 4.736