Literature DB >> 15583347

Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection.

Preeti Pancholi1, Steven Park, David Perlin, Christine Kubin, Phyllis Della-Latta.   

Abstract

Ocular yeast infections in diabetics are a therapeutic challenge. Drug resistance and reduced azole susceptibility are major concerns. The case we describe characterizes a Candida albicans strain from a vitrectomy specimen that was susceptible to fluconazole by in vitro testing but recalcitrant to therapy. Molecular studies revealed transient overexpression of CDR1 and ERG11 mRNA in the presence of fluconazole that may have contributed to poor clinical response in this patient.

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Year:  2004        PMID： 15583347      PMCID： PMC535233          DOI： 10.1128/JCM.42.12.5938-5939.2004

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  8 in total

1.  Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients.

Authors:  K Maebashi; M Niimi; M Kudoh; F J Fischer; K Makimura; K Niimi; R J Piper; K Uchida; M Arisawa; R D Cannon; H Yamaguchi
Journal:  J Antimicrob Chemother       Date:  2001-05       Impact factor: 5.790

2.  Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.

Authors:  S Perea; J L López-Ribot; W R Kirkpatrick; R K McAtee; R A Santillán; M Martínez; D Calabrese; D Sanglard; T F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

3.  Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus.

Authors:  T C White
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

4.  Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

Authors:  Adriana M Nascimento; Gustavo H Goldman; Steven Park; Salvatore A E Marras; Guillaume Delmas; Uma Oza; Karen Lolans; Michael N Dudley; Paul A Mann; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

5.  Identification of Candida dubliniensis based on temperature and utilization of xylose and alpha-methyl-D-glucoside as determined with the API 20C AUX and vitek YBC systems.

Authors:  A C Gales; M A Pfaller; A K Houston; S Joly; D J Sullivan; D C Coleman; D R Soll
Journal:  J Clin Microbiol       Date:  1999-12       Impact factor: 5.948

6.  Rapid identification of Candida dubliniensis using a species-specific molecular beacon.

Authors:  S Park; M Wong; S A Marras; E W Cross; T E Kiehn; V Chaturvedi; S Tyagi; D S Perlin
Journal:  J Clin Microbiol       Date:  2000-08       Impact factor: 5.948

7.  Rapid identification of Candida dubliniensis with commercial yeast identification systems.

Authors:  D H Pincus; D C Coleman; W R Pruitt; A A Padhye; I F Salkin; M Geimer; A Bassel; D J Sullivan; M Clarke; V Hearn
Journal:  J Clin Microbiol       Date:  1999-11       Impact factor: 5.948

8.  Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.

Authors:  Sofia Perea; José L López-Ribot; Brian L Wickes; William R Kirkpatrick; Olga P Dib; Stefano P Bachmann; Suzanne M Keller; Marcos Martinez; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191
  8 in total
  1 in total

Review 1.  Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

Authors:  Prit Lakhani; Akash Patil; Soumyajit Majumdar
Journal:  J Ocul Pharmacol Ther       Date:  2018-11-08       Impact factor: 2.671
  1 in total

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