| Literature DB >> 15582753 |
Nikolaos Pitsikas1, Antonello E Rigamonti, Silvano G Cella, Nikolaos Sakellaridis, Eugenio E Muller.
Abstract
The effects of the nitric oxide (NO) donor molsidomine on aged rats' cognition were evaluated in two different behavioral tasks: the step-through passive avoidance paradigm and the object recognition test. Post-training injection of molsidomine (at 4 but not at 2 mg/kg) significantly counteracted the performance deficits displayed by old rats in both the behavioral paradigms. These results support and extend prior findings about the implication of NO in learning and memory mechanisms. In addition, for the first time, a NO donor was found to antagonize age-related memory impairments, suggesting that the integrity of the NO-ergic system may be important in brain aging processes.Entities:
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Year: 2005 PMID： 15582753 DOI： 10.1016/j.neurobiolaging.2004.04.003
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673