Literature DB >> 15582443

Synthesis and in vitro study of novel Mannich bases as antibacterial agents.

Sheela Joshi1, Navita Khosla, Deepak Khare, Rakesh Sharda.   

Abstract

A series of novel Mannich bases derived from 5-chloro-2-methoxybenzamide and sulfonamides/amines have been synthesised and the antibacterial activities were evaluated against various Gram positive and Gram negative strains of bacteria. Some of the synthesized compounds showed superior in vitro activities as compared to their parent sulfonamides.

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Year:  2005        PMID: 15582443     DOI: 10.1016/j.bmcl.2004.09.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

2.  Identification of mannich base as a novel inhibitor of Mycobacterium tuberculosis isocitrate by high-throughput screening.

Authors:  Lei Ji; Quanxin Long; Dacheng Yang; Jianping Xie
Journal:  Int J Biol Sci       Date:  2011-04-07       Impact factor: 6.580

3.  Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.

Authors:  Olayinka O Ajani; Oluwole B Familoni; Feipeng Wu; Johnbull O Echeme; Zheng Sujiang
Journal:  Int J Med Chem       Date:  2012-10-17
  3 in total

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