| Literature DB >> 15582440 |
Mamta Thakur1, Abhilash Thakur, Padmakar V Khadikar, Claudiu T Supuran.
Abstract
The paper describes the dominating role of surface tension (ST) on the modeling, monitoring, and estimating pK(a) for a large series of 43 substituted sulfonamides. Because of the direct correlation of ST with parachor (Pc) vis-a-vis molecular volume (MV), ST is considered as a steric parameter. Single as well as multi-parametric regressions have indicated that ST has a dominating role in QSAR of the set of sulfonamides used and that excellent results are obtained in multi-parametric regression analysis. The results are discussed critically on the basis of statistical parameters.Entities:
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Year: 2005 PMID： 15582440 DOI： 10.1016/j.bmcl.2004.10.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823