| Literature DB >> 15582406 |
Vadim A Makarov1, Olga B Riabova, Vladimir G Granik, Hans-Martin Dahse, Axel Stelzner, Peter Wutzler, Michaela Schmidtke.
Abstract
A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical beta-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.Entities:
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Year: 2005 PMID： 15582406 DOI： 10.1016/j.bmcl.2004.10.043
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823