Literature DB >> 15582405

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.

Jennifer X Qiao1, Xuhong Cheng, Dilip P Modi, Karen A Rossi, Joseph M Luettgen, Robert M Knabb, Prabhakar K Jadhav, Ruth R Wexler.   

Abstract

Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.

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Year:  2005        PMID: 15582405     DOI: 10.1016/j.bmcl.2004.10.045

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  One-pot regioselective C-H activation iodination-cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source.

Authors:  Ziqiao Yan; Banlai Ouyang; Xunchun Mao; Wei Gao; Zhihong Deng; Yiyuan Peng
Journal:  RSC Adv       Date:  2019-06-11       Impact factor: 4.036

  1 in total

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