Literature DB >> 15582404

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

Jeremy N Burrows1, John G Cumming, Shaun M Fillery, Gordon A Hamlin, Julian A Hudson, Ruth J Jackson, Sharon McLaughlin, John S Shaw.   

Abstract

Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.

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Year:  2005        PMID： 15582404     DOI： 10.1016/j.bmcl.2004.10.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Investigation of substituent effect of 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides on CCR5 binding affinity using QSAR and virtual screening techniques.

Authors:  Antreas Afantitis; Georgia Melagraki; Haralambos Sarimveis; Panayiotis A Koutentis; John Markopoulos; Olga Igglessi-Markopoulou
Journal:  J Comput Aided Mol Des       Date:  2006-05-09       Impact factor: 3.686

2.  3D-QSAR studies of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas as CCR5 receptor antagonists.

Authors:  Yogesh D Aher; Avantika Agrawal; Prasad V Bharatam; Prabha Garg
Journal:  J Mol Model       Date:  2007-02-16       Impact factor: 1.810

3.  Metal-free hydroarylation of the side chain carbon-carbon double bond of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles in triflic acid.

Authors:  Anna S Zalivatskaya; Dmitry S Ryabukhin; Marina V Tarasenko; Alexander Yu Ivanov; Irina A Boyarskaya; Elena V Grinenko; Ludmila V Osetrova; Eugeniy R Kofanov; Aleksander V Vasilyev
Journal:  Beilstein J Org Chem       Date:  2017-05-11       Impact factor: 2.883
  3 in total

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