OBJECTIVE: This study was designed to evaluate the effect of adjuvant chemotherapy with carboplatin and etoposide in patients with completely resected stage IB-III dysgerminoma. METHODS: Eligible patients were treated with three courses of carboplatin 400 mg/m(2) on day 1 plus etoposide 120 mg/m(2) on days 1, 2, and 3 every 4 weeks for three courses. RESULTS: Forty-two patients were entered on this trial, of whom 39 were eligible. No patient suffered a recurrence of dysgerminoma, but one patient ultimately died of lung adenocarcinoma. One patient was excluded on pathology review (elements of endodermal sinus tumor were present) developed recurrent tumor and died despite further therapy. As expected, the regimen was well tolerated. Median follow-up of surviving patients is 7.8 years (range: 2.86 months to 10.92 years). CONCLUSION: The regimen used in this study is an alternative to cisplatin, etoposide, and bleomycin (BEP) for selected patients for whom minimizing toxicity (particularly neuropathy) is critical or for whom reduction in the number of treatment days is important.
OBJECTIVE: This study was designed to evaluate the effect of adjuvant chemotherapy with carboplatin and etoposide in patients with completely resected stage IB-III dysgerminoma. METHODS: Eligible patients were treated with three courses of carboplatin 400 mg/m(2) on day 1 plus etoposide 120 mg/m(2) on days 1, 2, and 3 every 4 weeks for three courses. RESULTS: Forty-two patients were entered on this trial, of whom 39 were eligible. No patient suffered a recurrence of dysgerminoma, but one patient ultimately died of lung adenocarcinoma. One patient was excluded on pathology review (elements of endodermal sinus tumor were present) developed recurrent tumor and died despite further therapy. As expected, the regimen was well tolerated. Median follow-up of surviving patients is 7.8 years (range: 2.86 months to 10.92 years). CONCLUSION: The regimen used in this study is an alternative to cisplatin, etoposide, and bleomycin (BEP) for selected patients for whom minimizing toxicity (particularly neuropathy) is critical or for whom reduction in the number of treatment days is important.
Authors: Victoria Champion; Stephen D Williams; Anna Miller; Kristina M Reuille; Kim Wagler-Ziner; Patrick O Monahan; Qianqian Zhao; David Gershenson; David Cella Journal: Gynecol Oncol Date: 2007-03-13 Impact factor: 5.482
Authors: John K Chan; Krishnansu S Tewari; Sarah Waller; Michael K Cheung; Jacob Y Shin; Kathryn Osann; Daniel S Kapp Journal: J Surg Oncol Date: 2008-08-01 Impact factor: 3.454
Authors: Daniela Matei; Anna M Miller; Patrick Monahan; David Gershenson; Qianqian Zhao; David Cella; Victoria L Champion; Stephen D Williams Journal: J Clin Oncol Date: 2009-07-27 Impact factor: 44.544
Authors: Bhavana Pothuri; Angeles Alvarez Secord; Deborah K Armstrong; John Chan; Amanda N Fader; Warner Huh; Joshua Kesterson; Joyce F Liu; Kathleen Moore; Shannon N Westin; R Wendel Naumann Journal: Gynecol Oncol Date: 2020-04-23 Impact factor: 5.482
Authors: Asaf Maoz; Koji Matsuo; Marcia A Ciccone; Shinya Matsuzaki; Maximilian Klar; Lynda D Roman; Anil K Sood; David M Gershenson Journal: Cancers (Basel) Date: 2020-05-29 Impact factor: 6.639