Literature DB >> 15578717

Nuclear or cytoplasmic expression of survivin: what is the significance?

Fengzhi Li1, Jie Yang, Nithya Ramnath, Milind M Javle, Dongfeng Tan.   

Abstract

Growing evidence suggests that survivin expression in cancer cell nuclei may represent an important prognostic marker to predict disease outcome for cancer patients. Current reports in this research area, however, are inconsistent and propose opposing conclusions regarding the significance and prognostic value of survivin nuclear expression. The aim of our study is to review and discuss the data reported in the original publications. We have also provided new experimental data to support our view regarding the possible reasons for the observed inconsistencies in the literature. This would alert researchers to pay attention to potential pitfalls in the determination of nuclear or cytoplasmic expression of survivin for the future.

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Year:  2005        PMID： 15578717      PMCID： PMC2829944          DOI： 10.1002/ijc.20768

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  29 in total

1.  HBXIP functions as a cofactor of survivin in apoptosis suppression.

Authors:  Hiroyuki Marusawa; Shu-Ichi Matsuzawa; Kate Welsh; Hua Zou; Robert Armstrong; Ingo Tamm; John C Reed
Journal:  EMBO J       Date:  2003-06-02       Impact factor: 11.598

Review 2.  Survivin study: what is the next wave?

Authors:  Fengzhi Li
Journal:  J Cell Physiol       Date:  2003-10       Impact factor: 6.384

3.  Survivin expression in human osteosarcoma is a marker for survival.

Authors:  K Trieb; R Lehner; T Stulnig; I Sulzbacher; K R Shroyer
Journal:  Eur J Surg Oncol       Date:  2003-05       Impact factor: 4.424

4.  Survivin, a potential early predictor of tumor progression in the oral mucosa.

Authors:  L Lo Muzio; G Pannone; R Leonardi; S Staibano; M D Mignogna; G De Rosa; Y Kudo; T Takata; D C Altieri
Journal:  J Dent Res       Date:  2003-11       Impact factor: 6.116

5.  Survivin gene expression in early-stage non-small cell lung cancer.

Authors:  Monica Falleni; Caterina Pellegrini; Antonio Marchetti; Barbara Oprandi; Fiamma Buttitta; Fabio Barassi; Luigi Santambrogio; Guido Coggi; Silvano Bosari
Journal:  J Pathol       Date:  2003-08       Impact factor: 7.996

6.  Survivin expression in the stomach: implications for mucosal integrity and protection.

Authors:  Shiun-Kwei Chiou; Woo Sung Moon; Michael K Jones; Andrzej S Tarnawski
Journal:  Biochem Biophys Res Commun       Date:  2003-05-30       Impact factor: 3.575

7.  Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis.

Authors:  Cynthia Cohen; Christina M Lohmann; George Cotsonis; Diane Lawson; Robert Santoianni
Journal:  Mod Pathol       Date:  2003-06       Impact factor: 7.842

8.  Prognostic importance of survivin in breast cancer.

Authors:  S M Kennedy; L O'Driscoll; R Purcell; N Fitz-Simons; E W McDermott; A D Hill; N J O'Higgins; M Parkinson; R Linehan; M Clynes
Journal:  Br J Cancer       Date:  2003-04-07       Impact factor: 7.640

9.  Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.

Authors:  R A Altura; R S Olshefski; Y Jiang; D R Boué
Journal:  Br J Cancer       Date:  2003-11-03       Impact factor: 7.640

10.  Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma.

Authors:  P Grabowski; T Kühnel; F Mühr-Wilkenshoff; B Heine; H Stein; M Höpfner; C T Germer; H Scherübl
Journal:  Br J Cancer       Date:  2003-01-13       Impact factor: 7.640
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  76 in total

1.  Immunoexpression of Survivin in non-neoplastic lymphoid tissues and malignant lymphomas using a new monoclonal antibody reactive on paraffin sections.

Authors:  José Vassallo; Talal Al Saati; Randy D Gascoyne; Kathyrn Welsh; John C Reed; Pierre Brousset; Georges Delsol
Journal:  J Hematop       Date:  2010-01-30       Impact factor: 0.196

2.  The CRM1 nuclear export protein in normal development and disease.

Authors:  Kevin T Nguyen; Michael P Holloway; Rachel A Altura
Journal:  Int J Biochem Mol Biol       Date:  2012-05-18

Review 3.  Role of the Survivin gene in pathophysiology.

Authors:  Fengzhi Li; Michael G Brattain
Journal:  Am J Pathol       Date:  2006-07       Impact factor: 4.307

4.  Characterization of the 12C4 survivin monoclonal antibody and insight into the expression of survivin in human adult tissues.

Authors:  B Spaulding; D Pan; A Ghadersohi; G Nielsen; S Jensen; F Gellert; X Ling; M Zhang; A Black; F Li
Journal:  Histopathology       Date:  2006-12       Impact factor: 5.087

5.  High expression of nuclear survivin and Aurora B predicts poor overall survival in patients with head and neck squamous cell cancer.

Authors:  O P Erpolat; P U Gocun; M Akmansu; E Karakus; G Akyol
Journal:  Strahlenther Onkol       Date:  2012-02-08       Impact factor: 3.621

6.  Survivin expressions in human hepatoma HepG2 cells exposed to ionizing radiation of different LET.

Authors:  Xiao-Dong Jin; Li Gong; Chuan-Ling Guo; Ji-Fang Hao; Wei Wei; Zhong-Ying Dai; Qiang Li
Journal:  Radiat Environ Biophys       Date:  2008-03-14       Impact factor: 1.925

7.  Cytoplasmic localization of wild-type survivin is associated with constitutive activation of the PI3K/Akt signaling pathway and represents a favorable prognostic factor in patients with acute myeloid leukemia.

Authors:  Juana Serrano-López; Josefina Serrano; Vianihuini Figueroa; Antonio Torres-Gomez; Salvador Tabares; Javier Casaño; Noemi Fernandez-Escalada; Joaquín Sánchez-Garcia
Journal:  Haematologica       Date:  2013-06-28       Impact factor: 9.941

8.  Response prediction to oxaliplatin plus 5-fluorouracil chemotherapy in patients with colorectal cancer using a four-protein immunohistochemical model.

Authors:  Junjie Gu; Zhe Li; Jianfeng Zhou; Zhao Sun; Chunmei Bai
Journal:  Oncol Lett       Date:  2019-06-14       Impact factor: 2.967

9.  Association of cigarette smoking with the expression of nuclear survivin in pathological Stage IA lung adenocarcinomas.

Authors:  Hiroshi Hirano; Hajime Maeda; Yukiyasu Takeuchi; Yoshiyuki Susaki; Ryoji Kobayashi; Akio Hayashi; Naoko Ose; Yukie Nakazawa; Toshihiko Yamaguchi; Soichiro Yokota; Masahide Mori
Journal:  Med Mol Morphol       Date:  2013-11-09       Impact factor: 2.309

10.  Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer.

Authors:  Donal J Brennan; Elton Rexhepaj; Sallyann L O'Brien; Elaine McSherry; Darran P O'Connor; Ailís Fagan; Aedín C Culhane; Desmond G Higgins; Karin Jirstrom; Robert C Millikan; Goran Landberg; Michael J Duffy; Stephen M Hewitt; William M Gallagher
Journal:  Clin Cancer Res       Date:  2008-05-01       Impact factor: 12.531
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