Robert C Baldwin1. 1. Manchester Mental Health and Social Care Trust, Manchester Royal Infirmary, Manchester M13 9WL, UK. Robert.Baldwin@man.ac.uk
Abstract
BACKGROUND: Vascular depression is an important conceptual and clinical concept. OBJECTIVE: To apply criteria which, in an ideal world, should be satisfied before an association between depression and vascular disease can be considered robust. METHOD: A literature review with discussion of findings in the light of recently suggested guidelines for the development of new psychiatric disorders. RESULTS: There is considerable evidence linking depression in later life with vascular brain disease but the interaction is bi-directional. Depression and vascular disease could be mediated by factors other than traditional vascular risk factors. There is increasing interest in mechanisms such as inflammatory processes which may mediate both depression and vascular disease. CONCLUSIONS: Vascular depression provides a useful framework with which to remind the clinician of important interactions between depression and vascular disease but conceptually it may be too restrictive.
BACKGROUND:Vascular depression is an important conceptual and clinical concept. OBJECTIVE: To apply criteria which, in an ideal world, should be satisfied before an association between depression and vascular disease can be considered robust. METHOD: A literature review with discussion of findings in the light of recently suggested guidelines for the development of new psychiatric disorders. RESULTS: There is considerable evidence linking depression in later life with vascular brain disease but the interaction is bi-directional. Depression and vascular disease could be mediated by factors other than traditional vascular risk factors. There is increasing interest in mechanisms such as inflammatory processes which may mediate both depression and vascular disease. CONCLUSIONS:Vascular depression provides a useful framework with which to remind the clinician of important interactions between depression and vascular disease but conceptually it may be too restrictive.
Authors: Carrington Rice Wendell; Megan M Hosey; David M Lefkowitz; Leslie I Katzel; Eliot L Siegel; William F Rosenberger; Shari R Waldstein Journal: Am J Geriatr Psychiatry Date: 2010-10 Impact factor: 4.105
Authors: Helen Lavretsky; Ling Zheng; Michael W Weiner; Dan Mungas; Bruce Reed; Joel H Kramer; William Jagust; Helena Chui; Wendy J Mack Journal: Int J Geriatr Psychiatry Date: 2008-10 Impact factor: 3.485
Authors: Anisha Kalidindi; Sean D Kelly; Kaela S Singleton; Dora Guzman; Liana Merrill; Stephanie L Willard; Carol A Shively; Gretchen N Neigh Journal: Physiol Behav Date: 2016-07-14
Authors: Andrea Salonia; Paolo Capogrosso; Maria Chiara Clementi; Giulia Castagna; Rocco Damiano; Francesco Montorsi Journal: Arab J Urol Date: 2013-09-14