OBJECTIVES: To determine risk factors associated with adverse developmental outcome at 5 years in extremely low birth weight infants or extremely premature infants (<28 weeks) with normal neonatal cranial ultrasounds. DESIGN/ METHODS: Data were collected prospectively on 152 infants with gestation <28 weeks or birth-weight <1000 g. Infants were grouped into those with normal development, mild-to-moderate impairment (IQ 70 to 84, or hearing loss 30 to 89 dB, visual acuity 6/18 to 6/60, or mild/moderate cerebral palsy (CP)) and severe impairment (IQ <70, hearing loss > or =90 dB, visual acuity <6/60, or severe CP). RESULTS: Five-year outcomes were available for 144/152 children (95%). In all, 89 (62%) infants had normal development, 39 (27%) had mild-moderate impairment and 16 (11%) had severe impairment. On multivariate logistic regression analysis, factors associated with developmental impairment were serum bilirubin > or =200 micromol/l (odds ratio (OR) - 4.06, p=0.003) and retinopathy of prematurity (ROP) (OR - 1.6, p=0.03). CONCLUSIONS: A serum bilirubin > or =200 micromol/l and presence of ROP are postnatal risk factors associated with an adverse developmental outcome in infants with normal cranial ultrasounds.
OBJECTIVES: To determine risk factors associated with adverse developmental outcome at 5 years in extremely low birth weight infants or extremely premature infants (<28 weeks) with normal neonatal cranial ultrasounds. DESIGN/ METHODS: Data were collected prospectively on 152 infants with gestation <28 weeks or birth-weight <1000 g. Infants were grouped into those with normal development, mild-to-moderate impairment (IQ 70 to 84, or hearing loss 30 to 89 dB, visual acuity 6/18 to 6/60, or mild/moderate cerebral palsy (CP)) and severe impairment (IQ <70, hearing loss > or =90 dB, visual acuity <6/60, or severe CP). RESULTS: Five-year outcomes were available for 144/152 children (95%). In all, 89 (62%) infants had normal development, 39 (27%) had mild-moderate impairment and 16 (11%) had severe impairment. On multivariate logistic regression analysis, factors associated with developmental impairment were serum bilirubin > or =200 micromol/l (odds ratio (OR) - 4.06, p=0.003) and retinopathy of prematurity (ROP) (OR - 1.6, p=0.03). CONCLUSIONS: A serum bilirubin > or =200 micromol/l and presence of ROP are postnatal risk factors associated with an adverse developmental outcome in infants with normal cranial ultrasounds.
Authors: Adriana S Lopez; Tatiana M Lanzieri; Angelika H Claussen; Sherry S Vinson; Marie R Turcich; Isabella R Iovino; Robert G Voigt; A Chantal Caviness; Jerry A Miller; W Daniel Williamson; Craig M Hales; Stephanie R Bialek; Gail Demmler-Harrison Journal: Pediatrics Date: 2017-11 Impact factor: 7.124
Authors: Jane E Brumbaugh; Edward F Bell; Shawn C Hirsch; Emma G Crenshaw; Sara B DeMauro; Ira S Adams-Chapman; Jean R Lowe; Girija Natarajan; Myra H Wyckoff; Betty R Vohr; Tarah T Colaizy; Heidi M Harmon; Kristi L Watterberg; Susan R Hintz Journal: Pediatr Res Date: 2021-10-22 Impact factor: 3.756
Authors: Karl C K Kuban; Elizabeth N Allred; T Michael O'Shea; Nigel Paneth; Marcello Pagano; Olaf Dammann; Alan Leviton; Adré Du Plessis; Sjirk J Westra; Cindy R Miller; Haim Bassan; Kalpathy Krishnamoorthy; Joseph Junewick; Nicholas Olomu; Elaine Romano; Joanna Seibert; Steve Engelke; Padmani Karna; Daniel Batton; Sunila E O'Connor; Cecelia E Keller Journal: J Child Neurol Date: 2009-01 Impact factor: 1.987
Authors: T M Lanzieri; J Leung; A C Caviness; W Chung; M Flores; P Blum; S R Bialek; J A Miller; S S Vinson; M R Turcich; R G Voigt; G Demmler-Harrison Journal: J Perinatol Date: 2017-04-06 Impact factor: 2.521