OBJECTIVE: A decrease in the prevalence of drug resistance (DR) has been observed among recently infected (RI) individuals in Montreal. A study of chronically infected (CI) patients, who represent potential HIV-1 transmitters, was carried out in order to ascertain biological factors associated with this trend change. DESIGN AND METHODS: Retrospective analysis of CI patients was performed for the period 1996-2003. Changes in mean viral load and DR prevalence were assessed in CI patients (n = 2328) and compared to those in RI patients (n = 180) living in the same geographic area. RESULTS: A decrease was observed in the prevalence of DR among RI patients, from 13.0% in 1997-2000 to 4.0% in 2001-2003 (P = 0.04). From 1996 to 2000, the mean viral load in the CI patients decreased by 1.34 log10, to remain steady thereafter. The proportion of CI patients who interrupt treatment increased steadily over 1997-2003 from 3.1% to 16.5% (P < 0.0001). Since 1999, when genotyping analysis became available, we have observed a 0.9 log10 decrease in mean viral load among 602 genotyped CI patients harbouring any major mutations. CONCLUSION: The decrease in transmission of DR documented in Montreal since 2000 coincides with the drop in mean viral load observed in CI patients. Factors that contribute to the decrease in viral load include routine access to genotyping and availability of more potent antiretroviral drugs. Plasma viral load seems to represent the main predictor for the transmission of DR.
OBJECTIVE: A decrease in the prevalence of drug resistance (DR) has been observed among recently infected (RI) individuals in Montreal. A study of chronically infected (CI) patients, who represent potential HIV-1 transmitters, was carried out in order to ascertain biological factors associated with this trend change. DESIGN AND METHODS: Retrospective analysis of CI patients was performed for the period 1996-2003. Changes in mean viral load and DR prevalence were assessed in CI patients (n = 2328) and compared to those in RI patients (n = 180) living in the same geographic area. RESULTS: A decrease was observed in the prevalence of DR among RI patients, from 13.0% in 1997-2000 to 4.0% in 2001-2003 (P = 0.04). From 1996 to 2000, the mean viral load in the CI patients decreased by 1.34 log10, to remain steady thereafter. The proportion of CI patients who interrupt treatment increased steadily over 1997-2003 from 3.1% to 16.5% (P < 0.0001). Since 1999, when genotyping analysis became available, we have observed a 0.9 log10 decrease in mean viral load among 602 genotyped CI patients harbouring any major mutations. CONCLUSION: The decrease in transmission of DR documented in Montreal since 2000 coincides with the drop in mean viral load observed in CI patients. Factors that contribute to the decrease in viral load include routine access to genotyping and availability of more potent antiretroviral drugs. Plasma viral load seems to represent the main predictor for the transmission of DR.
Authors: Katharine J Bar; Hui Li; Annie Chamberland; Cecile Tremblay; Jean Pierre Routy; Truman Grayson; Chuanxi Sun; Shuyi Wang; Gerald H Learn; Charity J Morgan; Joseph E Schumacher; Barton F Haynes; Brandon F Keele; Beatrice H Hahn; George M Shaw Journal: J Virol Date: 2010-04-07 Impact factor: 5.103
Authors: Bluma G Brenner; Michel Roger; Daniela D Moisi; Maureen Oliveira; Isabelle Hardy; Reuven Turgel; Hugues Charest; Jean-Pierre Routy; Mark A Wainberg Journal: AIDS Date: 2008-11-30 Impact factor: 4.177
Authors: Bluma G Brenner; Ruxandra-Ilinca Ibanescu; Maureen Oliveira; Michel Roger; Isabelle Hardy; Jean-Pierre Routy; Fred Kyeyune; Miguel E Quiñones-Mateu; Mark A Wainberg Journal: J Antimicrob Chemother Date: 2017-08-01 Impact factor: 5.790
Authors: Dineke Frentz; David van de Vijver; Ana Abecasis; Jan Albert; Osamah Hamouda; Louise Jørgensen; Claudia Kücherer; Daniel Struck; Jean-Claude Schmit; Jurgen Vercauteren; Birgitta Asjö; Claudia Balotta; Colm Bergin; Danail Beshkov; Ricardo Camacho; Bonaventura Clotet; Algirdas Griskevicius; Zehava Grossman; Andrzej Horban; Tatjana Kolupajeva; Klaus Korn; Leondios Kostrikis; Kirsi Liitsola Marek Linka; Claus Nielsen; Dan Otelea; Dimitrios Paraskevis; Roger Paredes; Mario Poljak; Elisabeth Puchhammer-Stöckl; Anders Sönnerborg; Danica Stanekova; Maja Stanojevic; Anne-Mieke Vandamme; Charles Boucher; Annemarie Wensing Journal: PLoS One Date: 2014-04-10 Impact factor: 3.240