Literature DB >> 15577476

Asymptomatic osteonecrosis: should it be treated?

David S Hungerford1, Lynne C Jones.   

Abstract

Currently, there is no consensus regarding the treatment of precollapse osteonecrosis, particularly for asymptomatic osteonecrosis. With approximately 10,000 to 20,000 new cases of osteonecrosis a year, no single surgeon or center has the kind of experience that is able to address the most important questions concerning this disease. The literature strongly documents that symptoms of osteonecrosis will progress. Although the literature also supports the progression of asymptomatic osteonecrosis to symptomatic osteonecrosis on to collapse, that support is less convincing. Progression is proportional to lesion size, with small lesions (< 15% of femoral head involvement by volume) unlikely to progress. Although the results of core decompression have been somewhat controversial, the weight of the literature supports both the efficacy and safety of the procedure. The decision to treat osteonecrosis with core decompression is primarily based upon lesion size and stage of disease and does not necessarily depend on whether the patient is symptomatic. As large lesions (> 30% of the femoral head) are less likely to be successfully treated by core decompression and small lesions (< 15% of the femoral head) are less likely to progress, asymptomatic lesions within these ranges can be observed. The literature supports the position that moderately sized lesions (15-30% of the femoral head) should be treated by core decompression (with or without bone grafting).

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Year:  2004        PMID: 15577476

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN: 0009-921X            Impact factor:   4.176


  31 in total

Review 1.  Osteonecrosis in children after therapy for malignancy.

Authors:  Sue C Kaste; Evguenia J Karimova; Michael D Neel
Journal:  AJR Am J Roentgenol       Date:  2011-05       Impact factor: 3.959

2.  NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: endocrine challenges-thyroid dysfunction, growth impairment, bone health, & reproductive risks.

Authors:  Christopher C Dvorak; Clarisa R Gracia; Jean E Sanders; Edward Y Cheng; K Scott Baker; Michael A Pulsipher; Anna Petryk
Journal:  Biol Blood Marrow Transplant       Date:  2011-10-17       Impact factor: 5.742

3.  No differences in the efficacy among various core decompression modalities and non-operative treatment: a network meta-analysis.

Authors:  Byung-Ho Yoon; Young-Kyun Lee; Ki-Choul Kim; Yong-Chan Ha; Kyung-Hoi Koo
Journal:  Int Orthop       Date:  2018-05-31       Impact factor: 3.075

4.  CORR Insights(®): development of a mouse model of ischemic osteonecrosis.

Authors:  Bryan Samuel Margulies
Journal:  Clin Orthop Relat Res       Date:  2015-03-07       Impact factor: 4.176

5.  New preclinical porcine model of femoral head osteonecrosis to test mesenchymal stromal cell efficiency in regenerative medicine.

Authors:  Alexandre Poignard; Angélique Lebouvier; Madeleine Cavet; Alain Rahmouni; Charles-Henri Flouzat Lachaniette; Philippe Bierling; Hélène Rouard; Philippe Hernigou; Nathalie Chevallier
Journal:  Int Orthop       Date:  2014-05-09       Impact factor: 3.075

6.  National Cancer Institute, National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplantation Consortium First International Consensus Conference on late effects after pediatric hematopoietic cell transplantation: the need for pediatric-specific long-term follow-up guidelines.

Authors:  Michael A Pulsipher; Roderick Skinner; George B McDonald; Sangeeta Hingorani; Saro H Armenian; Kenneth R Cooke; Clarisa Gracia; Anna Petryk; Smita Bhatia; Nancy Bunin; Michael L Nieder; Christopher C Dvorak; Lillian Sung; Jean E Sanders; Joanne Kurtzberg; K Scott Baker
Journal:  Biol Blood Marrow Transplant       Date:  2012-01-14       Impact factor: 5.742

Review 7.  Current concepts on osteonecrosis of the femoral head.

Authors:  Joaquin Moya-Angeler; Arianna L Gianakos; Jordan C Villa; Amelia Ni; Joseph M Lane
Journal:  World J Orthop       Date:  2015-09-18

8.  Osteonecrosis of the femoral head in patients with type 1 human immunodeficiency virus infection: clinical analysis and review.

Authors:  Jean-Cyr Yombi; Bernard Vandercam; Dunja Wilmes; Jean-Emile Dubuc; Anne Vincent; Pierre-Louis Docquier
Journal:  Clin Rheumatol       Date:  2009-03-10       Impact factor: 2.980

9.  Biophysical stimulation in osteonecrosis of the femoral head.

Authors:  Massari Leo; Fini Milena; Cadossi Ruggero; Setti Stefania; Traina Giancarlo
Journal:  Indian J Orthop       Date:  2009-01       Impact factor: 1.251

10.  Lesion size changes in osteonecrosis of the femoral head: a long-term prospective study using MRI.

Authors:  Feng-chao Zhao; Zi-rong Li; Nian-fei Zhang; Bai-liang Wang; Wei Sun; Li-ming Cheng; Zhao-hui Liu
Journal:  Int Orthop       Date:  2009-06-17       Impact factor: 3.075

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