OBJECTIVE: To examine risk of childhood acute lymphoblastic leukemia (ALL) associated with maternal use of medications during pregnancy; in particular medications known or suspected to be teratogenic. METHODS: Seven hundred and eighty nine children (< 15 years old) diagnosed with ALL in the province of Quebec between 1980 and 2000 were recruited for study. A similar number of population based controls matched to cases (1:1) by sex and age were chosen from family allowance or health insurance files. Information was gathered via telephone interview with the subjects' parents. Data were analyzed using conditional logistic regression. RESULTS: Risk of childhood ALL was significantly increased in the offspring of mothers who reported using any medication (adjusted odds ratio (OR(adj)) = 1.3, 95% CI = 1.0-1.6) or any teratogenic medication (OR(adj) = 1.4, 95% CI = 1.1-1.9) during pregnancy. Among specific medication categories, only central nervous system depressants were associated with a significantly increased risk, although elevated odd ratios were found for anti-epileptics, immunosuppressants, oral contraceptives, and illicit drugs. Risk associated with use of teratogenic medications was higher with increased dose and in children diagnosed before two years of age. CONCLUSION: A modest increase in risk of ALL was found among children of mothers who used medication during pregnancy.
OBJECTIVE: To examine risk of childhood acute lymphoblastic leukemia (ALL) associated with maternal use of medications during pregnancy; in particular medications known or suspected to be teratogenic. METHODS: Seven hundred and eighty nine children (< 15 years old) diagnosed with ALL in the province of Quebec between 1980 and 2000 were recruited for study. A similar number of population based controls matched to cases (1:1) by sex and age were chosen from family allowance or health insurance files. Information was gathered via telephone interview with the subjects' parents. Data were analyzed using conditional logistic regression. RESULTS: Risk of childhood ALL was significantly increased in the offspring of mothers who reported using any medication (adjusted odds ratio (OR(adj)) = 1.3, 95% CI = 1.0-1.6) or any teratogenic medication (OR(adj) = 1.4, 95% CI = 1.1-1.9) during pregnancy. Among specific medication categories, only central nervous system depressants were associated with a significantly increased risk, although elevated odd ratios were found for anti-epileptics, immunosuppressants, oral contraceptives, and illicit drugs. Risk associated with use of teratogenic medications was higher with increased dose and in children diagnosed before two years of age. CONCLUSION: A modest increase in risk of ALL was found among children of mothers who used medication during pregnancy.
Authors: Wan Rosmawati Wan Ismail; Raudah Abdul Rahman; Nur Ashiqin Abd Rahman; Azman Atil; Azmawati Mohammed Nawi Journal: J Prev Med Public Health Date: 2019-07-02
Authors: Susan E Puumala; Logan G Spector; Melanie M Wall; Leslie L Robison; Nyla A Heerema; Michelle A Roesler; Julie A Ross Journal: Hum Reprod Date: 2010-04-10 Impact factor: 6.918
Authors: Catherine Metayer; Elizabeth Milne; John D Dockerty; Jacqueline Clavel; Maria S Pombo-de-Oliveira; Catharina Wesseling; Logan G Spector; Joachim Schüz; Eleni Petridou; Sameera Ezzat; Bruce K Armstrong; Jérémie Rudant; Sergio Koifman; Peter Kaatsch; Maria Moschovi; Wafaa M Rashed; Steve Selvin; Kathryn McCauley; Rayjean J Hung; Alice Y Kang; Claire Infante-Rivard Journal: Epidemiology Date: 2014-11 Impact factor: 4.822