[BMP and LMP-1 for intervertebral disc regeneration].

Some evidence indicates that intervertebral disc degeneration is associated with decreasing of matrix synthesis from disc cell. BMP-2 increased mRNA of aggrecan and Type II collagen. It also enhanced disc matrix (proteoglycan) production. Adenovirually mediated LMP-1 overexpression in intervertebral disc cells increased disc cell proteoglycan production through BMP-2 and BMP-7 mediated process.