| Literature DB >> 15575791 |
Jacqueline C S Woo1, Erik Fenster, Gregory R Dake.
Abstract
The conversion of sterically hindered carboxylic acids to N-methoxy-N-methyl amides can be efficiently carried out with 1.1 equiv of methanesulfonyl chloride, 3 equiv of triethylamine, and 1.1 equiv of N-methoxy-N-methylamine. Yields for this process range from 59% to 88%. The major byproduct in these reactions, N-methoxy-N-methylmethanesulfonamide, can be removed by placing the product mixture under vacuum for 14-24 h.Entities:
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Year: 2004 PMID： 15575791 DOI： 10.1021/jo048385h
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354