Literature DB >> 15574362

The immune system in aging: roles of cytokines, T cells and NK cells.

Hai Huang1, Dhavalkumar D Patel, Kenneth G Manton.   

Abstract

Aging is characterized by a proinflammatory state that contributes to the onset of disability and age-related diseases. Proinflammatory cytokines play a central role in mediating cellular and physiological responses. The levels of these cytokines may reflect immune system effectiveness. Studies of the effects of aging on inflammatory response show interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) to be important. In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered.

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Year:  2005        PMID： 15574362     DOI： 10.2741/1521

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  28 in total

Review 1.  Frontiers in the use of biomarkers of health in research on stress and aging.

Authors:  Jennifer R Piazza; David M Almeida; Natalia O Dmitrieva; Laura C Klein
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2010-07-20       Impact factor: 4.077

2.  Differential Impact of Obesity on CD69 Expression in Individuals with Bipolar Disorder and Healthy Controls.

Authors:  Ana S Yamagata; Lucas B Rizzo; Raphael O Cerqueira; Janine Scott; Quirino Cordeiro; Roger S McIntyre; Rodrigo B Mansur; Elisa Brietzke
Journal:  Mol Neuropsychiatry       Date:  2018-02-01

3.  [Chronic inflammation and biomarkers. Is ageing an expression of chronic inflammation?].

Authors:  D Schmidt; A Kwetkat; M Gogol
Journal:  Z Gerontol Geriatr       Date:  2011-06       Impact factor: 1.281

Review 4.  Changes of T-cell Immunity Over a Lifetime.

Authors:  Yeqi Nian; Koichiro Minami; Ryoichi Maenesono; Jasper Iske; Jinrui Yang; Haruhito Azuma; Abdala ElKhal; Stefan G Tullius
Journal:  Transplantation       Date:  2019-11       Impact factor: 4.939

5.  Immunity, cancer and aging: lessons from mouse models.

Authors:  Cheryl E Myers; Noweeda N Mirza; Joseph Lustgarten
Journal:  Aging Dis       Date:  2011-12-02       Impact factor: 6.745

6.  Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice.

Authors:  Yee Ting Wong; Jan Gruber; Andrew M Jenner; Francis Eng Hock Tay; Runsheng Ruan
Journal:  Age (Dordr)       Date:  2010-08-21

7.  Zinc-gene interaction related to inflammatory/immune response in ageing.

Authors:  Eugenio Mocchegiani; Marco Malavolta
Journal:  Genes Nutr       Date:  2008-07       Impact factor: 5.523

8.  Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling.

Authors:  Naeun Lee; Min Sun Shin; Ki Soo Kang; Seung-Ah Yoo; Subhasis Mohanty; Ruth R Montgomery; Albert C Shaw; Insoo Kang
Journal:  Clin Immunol       Date:  2014-03-19       Impact factor: 3.969

9.  Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal.

Authors:  Albert E Jergens; Ioana M Sonea; Annette M O'Connor; Linda K Kauffman; Sinisa D Grozdanic; Mark R Ackermann; Richard B Evans
Journal:  Comp Med       Date:  2009-04       Impact factor: 0.982

Review 10.  Towards retinoid therapy for Alzheimer's disease.

Authors:  K Shudo; H Fukasawa; M Nakagomi; N Yamagata
Journal:  Curr Alzheimer Res       Date:  2009-06       Impact factor: 3.498
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