Literature DB >> 1557394

A protein kinase associated with paired helical filaments in Alzheimer disease.

I J Vincent1, P Davies.   

Abstract

We have identified a protein kinase in immunoaffinity-purified preparations of paired helical filaments from brain tissue of individuals with Alzheimer disease. The kinase phosphorylates the filament proteins in vitro in a manner independent of second messenger regulation or of modulation by heparin and polyamines. Physiological concentrations of hemin, an oxidized heme porphyrin, inhibit the kinase and abolish Alz-50 immunoreactivity of the proteins. Since paired helical filaments are composed of hyperphosphorylated proteins, association of a protein kinase with the filaments provides a mechanism for abnormal processing of the proteins in disease.

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Year:  1992        PMID： 1557394      PMCID： PMC48766          DOI： 10.1073/pnas.89.7.2878

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

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Authors:  K Ishiguro; A Omori; K Sato; K Tomizawa; K Imahori; T Uchida
Journal:  Neurosci Lett       Date:  1991-07-22       Impact factor: 3.046

5.  Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques.

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Journal:  Neurosci Lett       Date:  1986-04-24       Impact factor: 3.046

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7.  The identification of monoclonal class switch variants by sib selection and an ELISA assay.

Authors:  G Spira; A Bargellesi; J L Teillaud; M D Scharff
Journal:  J Immunol Methods       Date:  1984-11-30       Impact factor: 2.303

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Journal:  Curr Top Cell Regul       Date:  1982

9.  Phosphorylation characteristics of the A68 protein in Alzheimer's disease.

Authors:  I J Vincent; P Davies
Journal:  Brain Res       Date:  1990-10-29       Impact factor: 3.252

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Authors:  S Love; P Burrola; R D Terry; C A Wiley
Journal:  Neuropathol Appl Neurobiol       Date:  1989 May-Jun       Impact factor: 8.090
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  10 in total

1.  A nucleated assembly mechanism of Alzheimer paired helical filaments.

Authors:  P Friedhoff; M von Bergen; E M Mandelkow; P Davies; E Mandelkow
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

2.  Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.

Authors:  T J Singh; T Zaidi; I Grundke-Iqbal; K Iqbal
Journal:  Mol Cell Biochem       Date:  1996-01-26       Impact factor: 3.396

Review 3.  Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration.

Authors:  M L Billingsley; R L Kincaid
Journal:  Biochem J       Date:  1997-05-01       Impact factor: 3.857

4.  Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.

Authors:  W K Liu; R T Williams; F L Hall; D W Dickson; S H Yen
Journal:  Am J Pathol       Date:  1995-01       Impact factor: 4.307

5.  Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

Authors:  B T Hyman; T E Elvhage; J Reiter
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

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Authors:  M Schorderet
Journal:  Experientia       Date:  1995-02-15

7.  Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases.

Authors:  T J Singh; I Grundke-Iqbal; B McDonald; K Iqbal
Journal:  Mol Cell Biochem       Date:  1994-02-23       Impact factor: 3.396

8.  Targeting gonadotropins: an alternative option for Alzheimer disease treatment.

Authors:  Gemma Casadesus; Emma Ramiro Puig; Kate M Webber; Craig S Atwood; Margarida Castell Escuer; Richard L Bowen; George Perry; Mark A Smith
Journal:  J Biomed Biotechnol       Date:  2006

9.  Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

Authors:  R M Xu; G Carmel; R M Sweet; J Kuret; X Cheng
Journal:  EMBO J       Date:  1995-03-01       Impact factor: 11.598

10.  Mitotic mechanisms in Alzheimer's disease?

Authors:  I Vincent; M Rosado; P Davies
Journal:  J Cell Biol       Date:  1996-02       Impact factor: 10.539
  10 in total

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