Literature DB >> 15573872

SCIO-469 Scios Inc.

Spyros N Nikas1, Alexandros A Drosos.   

Abstract

SCIO-469 is a small-molecule p38 mitogen-activated protein (MAP) kinase inhibitor under development by Scios Inc as a potential oral therapy for inflammatory disorders. By July 2004, SCIO-469 was in phase lib clinical trials for rheumatoid arthritis.

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Year:  2004        PMID： 15573872

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  8 in total

1.  Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors.

Authors:  Tony A Navas; Mani Mohindru; Myka Estes; Jing Ying Ma; Lubomir Sokol; Perry Pahanish; Simrit Parmar; Edwin Haghnazari; Li Zhou; Robert Collins; Irene Kerr; Aaron N Nguyen; Yin Xu; Leonidas C Platanias; Alan A List; Linda S Higgins; Amit Verma
Journal:  Blood       Date:  2006-08-29       Impact factor: 22.113

2.  Evaluation of the therapeutic potential of the selective p38 MAPK inhibitor Skepinone-L and the dual p38/JNK 3 inhibitor LN 950 in experimental K/BxN serum transfer arthritis.

Authors:  Philipp Guenthoer; Kerstin Fuchs; Gerald Reischl; Leticia Quintanilla-Martinez; Irene Gonzalez-Menendez; Stefan Laufer; Bernd J Pichler; Manfred Kneilling
Journal:  Inflammopharmacology       Date:  2019-04-29       Impact factor: 4.473

3.  Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human hepatoma cell lines.

Authors:  J Westra; J Bijzet; B Doornbos-van der Meer; M H van Rijswijk; P C Limburg
Journal:  Ann Rheum Dis       Date:  2005-11-03       Impact factor: 19.103

Review 4.  Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents.

Authors:  A M Mfuh; O V Larionov
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

5.  The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α.

Authors:  Yanek Jiménez-Andrade; Kathryn R Hillette; Toshimi Yoshida; Mariko Kashiwagi; Min-Kyung Choo; Yinming Liang; Katia Georgopoulos; Jin Mo Park
Journal:  J Immunol       Date:  2022-05-27       Impact factor: 5.426

Review 6.  NSAID therapy effects on healing of bone, tendon, and the enthesis.

Authors:  Bailey Su; J Patrick O'Connor
Journal:  J Appl Physiol (1985)       Date:  2013-07-18

Review 7.  Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis.

Authors:  Verica Paunovic; Margaret M Harnett
Journal:  Drugs       Date:  2013-02       Impact factor: 9.546

8.  p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice.

Authors:  Satoshi Marumo; Yuma Hoshino; Hirofumi Kiyokawa; Naoya Tanabe; Atsuyasu Sato; Emiko Ogawa; Shigeo Muro; Toyohiro Hirai; Michiaki Mishima
Journal:  BMC Pulm Med       Date:  2014-05-07       Impact factor: 3.317
  8 in total

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