Literature DB >> 15573100

Development of TGF-beta signalling inhibitors for cancer therapy.

Jonathan M Yingling1, Kerry L Blanchard, J Scott Sawyer.   

Abstract

The transforming growth factor-beta (TGF-beta) superfamily of ligands has a pivotal role in the regulation of a wide variety of physiological processes from development to pathogenesis. Since the discovery of the prototypic member, TGF-beta, almost 20 years ago, there have been tremendous advances in our understanding of the complex biology of this superfamily. Deregulation of TGF-beta has been implicated in the pathogenesis of a variety of diseases, including cancer and fibrosis. Here we present the rationale for evaluating TGF-beta signalling inhibitors as cancer therapeutics, the structures of small-molecule inhibitors that are in development and the targeted drug discovery model that is being applied to their development.

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Year:  2004        PMID： 15573100     DOI： 10.1038/nrd1580

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  194 in total

1.  Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.

Authors:  Penelope M Drake; Birgit Schilling; Richard K Niles; Akraporn Prakobphol; Bensheng Li; Kwanyoung Jung; Wonryeon Cho; Miles Braten; Halina D Inerowicz; Katherine Williams; Matthew Albertolle; Jason M Held; Demetris Iacovides; Dylan J Sorensen; Obi L Griffith; Eric Johansen; Anna M Zawadzka; Michael P Cusack; Simon Allen; Matthew Gormley; Steven C Hall; H Ewa Witkowska; Joe W Gray; Fred Regnier; Bradford W Gibson; Susan J Fisher
Journal:  J Proteome Res       Date:  2012-03-13       Impact factor: 4.466

2.  MicroRNA-19b Expression in Human Biliary Atresia Specimens and Its Role in BA-Related Fibrosis.

Authors:  Dong Zhao; Yi Luo; Yun Xia; Jian-Jun Zhang; Qiang Xia
Journal:  Dig Dis Sci       Date:  2017-01-12       Impact factor: 3.199

Review 3.  Liver metastases: Microenvironments and ex-vivo models.

Authors:  Amanda M Clark; Bo Ma; D Lansing Taylor; Linda Griffith; Alan Wells
Journal:  Exp Biol Med (Maywood)       Date:  2016-07-06

4.  Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events.

Authors:  Damian J Junk; Rocky Cipriano; Benjamin L Bryson; Hannah L Gilmore; Mark W Jackson
Journal:  Neoplasia       Date:  2013-09       Impact factor: 5.715

5.  Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis.

Authors:  Ashley M Lakner; Nury M Steuerwald; Tracy L Walling; Sriparna Ghosh; Ting Li; Iain H McKillop; Mark W Russo; Herbert L Bonkovsky; Laura W Schrum
Journal:  Hepatology       Date:  2012-06-18       Impact factor: 17.425

6.  Peptide ligands that use a novel binding site to target both TGF-β receptors.

Authors:  Lingyin Li; Brendan P Orner; Tao Huang; Andrew P Hinck; Laura L Kiessling
Journal:  Mol Biosyst       Date:  2010-10-04

7.  Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy.

Authors:  Samuel Kim; George Buchlis; Zvi G Fridlender; Jing Sun; Veena Kapoor; Guanjun Cheng; Andrew Haas; Hung Kam Cheung; Xiamei Zhang; Michael Corbley; Larry R Kaiser; Leona Ling; Steven M Albelda
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

8.  Integral role of platelet-derived growth factor in mediating transforming growth factor-β1-dependent mesenchymal stem cell stiffening.

Authors:  Deepraj Ghosh; Loukia Lili; Daniel J McGrail; Lilya V Matyunina; John F McDonald; Michelle R Dawson
Journal:  Stem Cells Dev       Date:  2013-11-08       Impact factor: 3.272

Review 9.  Targeting the transforming growth factor-beta signaling pathway in human cancer.

Authors:  Nagathihalli S Nagaraj; Pran K Datta
Journal:  Expert Opin Investig Drugs       Date:  2010-01       Impact factor: 6.206

10.  Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.

Authors:  Bixiang Zhang; Sunil K Halder; Sanguo Zhang; Pran K Datta
Journal:  Cancer Lett       Date:  2009-01-14       Impact factor: 8.679
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