BACKGROUND: Chlorpyrifos is one of the most widely used insecticides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. METHODS: A total of 54,383 pesticide applicators were included in this analysis. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered questionnaires completed at the time of enrollment (December 1993-December 1997). Poisson regression analysis was used to evaluate the association between chlorpyrifos exposure and cancer incidence after adjustment for potential confounders. All statistical tests were two-sided. RESULTS: A total of 2070 incident malignant neoplasms were diagnosed through 2001. The rate ratio for all cancers combined among chlorpyrifos-exposed applicators compared with nonexposed applicators was 0.97 (95% confidence interval = 0.87 to 1.08). For most cancers analyzed, there was no evidence of an exposure-response relationship. However, the incidence of lung cancer was statistically significantly associated with both chlorpyrifos lifetime exposure-days (P(trend) = .002) and chlorpyrifos intensity-weighted exposure-days (P(trend) = .036). After adjustment for other pesticide exposures and demographic factors, individuals in the highest quartile of chlorpyrifos lifetime exposure-days (>56 days) had a relative risk of lung cancer 2.18 (95% confidence interval = 1.31 to 3.64) times that of those with no chlorpyrifos exposure. CONCLUSION: Our findings suggest an association between chlorpyrifos use and incidence of lung cancer that deserves further evaluation.
BACKGROUND:Chlorpyrifos is one of the most widely used insecticides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. METHODS: A total of 54,383 pesticide applicators were included in this analysis. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered questionnaires completed at the time of enrollment (December 1993-December 1997). Poisson regression analysis was used to evaluate the association between chlorpyrifos exposure and cancer incidence after adjustment for potential confounders. All statistical tests were two-sided. RESULTS: A total of 2070 incident malignant neoplasms were diagnosed through 2001. The rate ratio for all cancers combined among chlorpyrifos-exposed applicators compared with nonexposed applicators was 0.97 (95% confidence interval = 0.87 to 1.08). For most cancers analyzed, there was no evidence of an exposure-response relationship. However, the incidence of lung cancer was statistically significantly associated with both chlorpyrifos lifetime exposure-days (P(trend) = .002) and chlorpyrifos intensity-weighted exposure-days (P(trend) = .036). After adjustment for other pesticide exposures and demographic factors, individuals in the highest quartile of chlorpyrifos lifetime exposure-days (>56 days) had a relative risk of lung cancer 2.18 (95% confidence interval = 1.31 to 3.64) times that of those with no chlorpyrifos exposure. CONCLUSION: Our findings suggest an association between chlorpyrifos use and incidence of lung cancer that deserves further evaluation.
Authors: Rena R Jones; Francesco Barone-Adesi; Stella Koutros; Catherine C Lerro; Aaron Blair; Jay Lubin; Sonya L Heltshe; Jane A Hoppin; Michael C R Alavanja; Laura E Beane Freeman Journal: Occup Environ Med Date: 2015-04-23 Impact factor: 4.402
Authors: Graciela Eugenia Bianco; Eva Suarez; Lauro Cazon; Teresita Beatriz de la Puente; Marcelo Rafael Benitez Ahrendts; Julio César De Luca Journal: Environ Sci Pollut Res Int Date: 2017-07-21 Impact factor: 4.223
Authors: Ryan C Lewis; David E Cantonwine; Liza V Anzalota Del Toro; Antonia M Calafat; Liza Valentin-Blasini; Mark D Davis; M Angela Montesano; Akram N Alshawabkeh; José F Cordero; John D Meeker Journal: Sci Total Environ Date: 2015-01-27 Impact factor: 7.963
Authors: J H Mandel; M A Kelsh; P J Mink; D D Alexander; R M Kalmes; M Weingart; L Yost; M Goodman Journal: Occup Environ Med Date: 2006-04-27 Impact factor: 4.402