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Literature DB >> 15572122

On the InterAktion between hexokinase and the mitochondrion.

Abstract

The protein kinase Akt is now well recognized as a potent inhibitor of apoptosis. Work published by Majewski et al. in the December 3rd issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by stimulating the translocation of hexokinase to the mitochondrion. Hexokinase, in turn, antagonizes the release of mitochondrial cytochrome C.

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Year: 2004 PMID： 15572122 DOI： 10.1016/j.devcel.2004.11.016

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

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Cited

11 in total

1. Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana.

Authors: Moonil Kim; Jeong-Hwa Lim; Chang Sook Ahn; Kyoungsook Park; Gyung Tae Kim; Woo Taek Kim; Hyun-Sook Pai
Journal: Plant Cell Date: 2006-08-18 Impact factor: 11.277

2. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

Authors: Chia-Hsin Chan; Chien-Feng Li; Wei-Lei Yang; Yuan Gao; Szu-Wei Lee; Zizhen Feng; Hsuan-Ying Huang; Kelvin K C Tsai; Leo G Flores; Yiping Shao; John D Hazle; Dihua Yu; Wenyi Wei; Dos Sarbassov; Mien-Chie Hung; Keiichi I Nakayama; Hui-Kuan Lin
Journal: Cell Date: 2012-05-25 Impact factor: 41.582

Review 3. Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.

Authors: Peter L Pedersen
Journal: J Bioenerg Biomembr Date: 2007-06 Impact factor: 2.945

4. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition.

Authors: Yongjun Fan; Kathleen G Dickman; Wei-Xing Zong
Journal: J Biol Chem Date: 2009-12-17 Impact factor: 5.157

5. Hexokinase II binding to mitochondria is necessary for Kupffer cell activation and is potentiated by ethanol exposure.

Authors: Nataly Shulga; John G Pastorino
Journal: J Biol Chem Date: 2014-08-05 Impact factor: 5.157

Review 10. Hexokinase-mitochondrial interaction in cardiac tissue: implications for cardiac glucose uptake, the 18FDG lumped constant and cardiac protection.

Authors: Richard Southworth
Journal: J Bioenerg Biomembr Date: 2009-04 Impact factor: 2.945

On the InterAktion between hexokinase and the mitochondrion.

1. Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana.

2. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

Review 3. Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.

4. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition.

5. Hexokinase II binding to mitochondria is necessary for Kupffer cell activation and is potentiated by ethanol exposure.

6. The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia.

Review 7. Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte.

8. Experimental analysis of the rice mitochondrial proteome, its biogenesis, and heterogeneity.

9. Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.

Review 10. Hexokinase-mitochondrial interaction in cardiac tissue: implications for cardiac glucose uptake, the 18FDG lumped constant and cardiac protection.