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Literature DB >> 15571816

Productive RUPture: activation of transcription factors by proteasomal processing.

Abstract

Proteasomes usually degrade proteins completely into small peptides. In a few cases, however, proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process, termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review, we summarize the available data and suggest a mechanistic model for proteasomal processing.

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Year: 2004 PMID： 15571816 DOI： 10.1016/j.bbamcr.2004.09.022

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

28 in total

1. The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.

Authors: Petra Hänzelmann; Julian Stingele; Kay Hofmann; Hermann Schindelin; Shahri Raasi
Journal: J Biol Chem Date: 2010-04-28 Impact factor: 5.157

Review 2. Ubiquitin signalling in the NF-kappaB pathway.

Authors: Zhijian J Chen
Journal: Nat Cell Biol Date: 2005-08 Impact factor: 28.824

3. m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria.

Authors: Takashi Tatsuta; Steffen Augustin; Mark Nolden; Björn Friedrichs; Thomas Langer
Journal: EMBO J Date: 2007-01-24 Impact factor: 11.598

Review 4. Reverse the curse--the role of deubiquitination in cell cycle control.

Authors: Ling Song; Michael Rape
Journal: Curr Opin Cell Biol Date: 2008-03-17 Impact factor: 8.382

5. Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.

Authors: María M Peñas; América Hervás-Aguilar; Tatiana Múnera-Huertas; Elena Reoyo; Miguel A Peñalva; Herbert N Arst; Joan Tilburn
Journal: Eukaryot Cell Date: 2007-04-06

Productive RUPture: activation of transcription factors by proteasomal processing.

1. The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.

Review 2. Ubiquitin signalling in the NF-kappaB pathway.

3. m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria.

Review 4. Reverse the curse--the role of deubiquitination in cell cycle control.

5. Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.

Review 6. Aging and regulated protein degradation: who has the UPPer hand?

7. Modulation of RNA polymerase II subunit composition by ubiquitylation.

8. Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.

9. Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding.

10. The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.