PURPOSE: The International League Against Epilepsy (ILAE) classification distinguishes medial and neocortical temporal lobe epilepsies. Among other criteria, this classification relies on the identification of two different electroclinical patterns, those of medial (limbic) and lateral (neocortical) temporal lobe seizures, depending on the structure initially involved in the seizure activity. Recent electrophysiologic studies have now identified seizures in which medial and neocortical structures are both involved at seizure onset. The purpose of the study was therefore to study the correlations of ictal semiology with the spatiotemporal pattern of discharge in temporal lobe seizures. METHODS: The 187 stereoelectroencephalography-recorded seizures from 55 patients were analyzed. Patients were classified into three groups according to electrophysiologic findings: medial (M; seizure onset limited to medial structures, n=24), lateral (L; seizure onset limited to lateral structures, n=13), and medial-lateral (ML; seizure onset involving both medial and lateral structures, n=18). Clinical findings were compared between groups. RESULTS: Initial epigastric sensation, initial fear, delayed oroalimentary and elementary upper limb automatisms, delayed loss of contact, long seizure duration, and absent or rare secondary generalizations were associated with M seizures. Initial auditory illusion or hallucination, initial loss of contact, shorter duration of seizures, and more frequent generalizations were associated with L seizures. Initial epigastric sensation, initial loss of contact, early oroalimentary and verbal automatisms, and long duration of seizures were associated with ML seizures. CONCLUSIONS: Although the syndrome of mesial temporal epilepsy is now relatively well defined, our findings support the idea that the organization of temporal lobe seizures may be complex and that different patterns exist. We demonstrate three distinct patterns, characterized by both semiologic and electrophysiologic features. This distinction may help to define better the epileptogenic zone and the subsequent surgical procedure.
PURPOSE: The International League Against Epilepsy (ILAE) classification distinguishes medial and neocortical temporal lobe epilepsies. Among other criteria, this classification relies on the identification of two different electroclinical patterns, those of medial (limbic) and lateral (neocortical) temporal lobe seizures, depending on the structure initially involved in the seizure activity. Recent electrophysiologic studies have now identified seizures in which medial and neocortical structures are both involved at seizure onset. The purpose of the study was therefore to study the correlations of ictal semiology with the spatiotemporal pattern of discharge in temporal lobe seizures. METHODS: The 187 stereoelectroencephalography-recorded seizures from 55 patients were analyzed. Patients were classified into three groups according to electrophysiologic findings: medial (M; seizure onset limited to medial structures, n=24), lateral (L; seizure onset limited to lateral structures, n=13), and medial-lateral (ML; seizure onset involving both medial and lateral structures, n=18). Clinical findings were compared between groups. RESULTS: Initial epigastric sensation, initial fear, delayed oroalimentary and elementary upper limb automatisms, delayed loss of contact, long seizure duration, and absent or rare secondary generalizations were associated with M seizures. Initial auditory illusion or hallucination, initial loss of contact, shorter duration of seizures, and more frequent generalizations were associated with L seizures. Initial epigastric sensation, initial loss of contact, early oroalimentary and verbal automatisms, and long duration of seizures were associated with ML seizures. CONCLUSIONS: Although the syndrome of mesial temporal epilepsy is now relatively well defined, our findings support the idea that the organization of temporal lobe seizures may be complex and that different patterns exist. We demonstrate three distinct patterns, characterized by both semiologic and electrophysiologic features. This distinction may help to define better the epileptogenic zone and the subsequent surgical procedure.
Authors: Guilherme Silva; Cristina Martins; Nádia Moreira da Silva; Duarte Vieira; Dias Costa; Ricardo Rego; José Fonseca; João Paulo Silva Cunha Journal: Neuroradiol J Date: 2017-06-20
Authors: Jamie J Van Gompel; Fredric B Meyer; W Richard Marsh; Kendall H Lee; Gregory A Worrell Journal: J Neurosurg Date: 2010-07 Impact factor: 5.115
Authors: Kanjana Unnwongse; Andreas V Alexopoulos; Robyn M Busch; Tim Wehner; Dileep Nair; William E Bingaman; Imad M Najm Journal: Neurology Date: 2013-10-30 Impact factor: 9.910
Authors: I S Mohamed; H Otsubo; E Pang; S H Chuang; J T Rutka; P Dirks; S K Weiss; O C Snead Journal: J Neurol Neurosurg Psychiatry Date: 2006-08-04 Impact factor: 10.154
Authors: Chengyuan Wu; Walter J Jermakowicz; Srijata Chakravorti; Iahn Cajigas; Ashwini D Sharan; Jonathan R Jagid; Caio M Matias; Michael R Sperling; Robert Buckley; Andrew Ko; Jeffrey G Ojemann; John W Miller; Brett Youngerman; Sameer A Sheth; Guy M McKhann; Adrian W Laxton; Daniel E Couture; Gautam S Popli; Alexander Smith; Ashesh D Mehta; Allen L Ho; Casey H Halpern; Dario J Englot; Joseph S Neimat; Peter E Konrad; Elliot Neal; Fernando L Vale; Kathryn L Holloway; Ellen L Air; Jason Schwalb; Benoit M Dawant; Pierre-Francois D'Haese Journal: Epilepsia Date: 2019-05-21 Impact factor: 5.864
Authors: Chandan G Reddy; Nader S Dahdaleh; Gregory Albert; Fangxiang Chen; Daniel Hansen; Kirill Nourski; Hiroto Kawasaki; Hiroyuki Oya; Matthew A Howard Journal: J Neurosurg Date: 2010-06 Impact factor: 5.115