| Literature DB >> 15569924 |
Johanna M Dela Cruz1, Igor Pastirk, Matthew Comstock, Vadim V Lozovoy, Marcos Dantus.
Abstract
We test whether coherent control methods based on ultrashort-pulse phase shaping can be applied when the laser light propagates through biological tissue. Our results demonstrate experimentally that the spectral-phase properties of shaped laser pulses optimized to achieve selective two-photon excitation survive as the laser pulses propagate through tissue. This observation is used to obtain functional images based on selective two-photon excitation of a pH-sensitive chromophore in a sample that is placed behind a slice of biological tissue. Our observation of coherent control through scattering tissue suggests possibilities in multiphoton-based imaging and photodynamic therapy.Mesh:
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Year: 2004 PMID: 15569924 PMCID: PMC534608 DOI: 10.1073/pnas.0407733101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205