Paul J Moberg1, David R Roalf, Raquel E Gur, Bruce I Turetsky. 1. Brain-Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St., Philadelphia, PA 19104, USA. moberg@bbl.med.upenn.edu
Abstract
OBJECTIVE: Anatomical and functional deficits of the olfactory neural system have been identified in patients with schizophrenia. Since olfactory structures develop in conjunction with both the palate and ventral forebrain, the authors hypothesized that schizophrenia patients might have structural abnormalities of the nasal cavity, which could represent specific markers of embryological dysmorphogenesis underlying schizophrenia. METHOD: A measurement of nasal volume was acquired by acoustic rhinometry for 40 male schizophrenia patients and 24 healthy male comparison subjects. RESULTS: The patients had smaller posterior nasal volumes than the comparison subjects but did not differ in anterior nasal volumes. This difference persisted after covarying for height and smoking history. CONCLUSIONS: The lower observed posterior nasal volume likely reflects a specific developmental craniofacial abnormality. This finding confirms an early disruption in embryological development in males with schizophrenia and may represent a genetic or environmental "first hit" that leaves the individual vulnerable to subsequent pathology.
OBJECTIVE: Anatomical and functional deficits of the olfactory neural system have been identified in patients with schizophrenia. Since olfactory structures develop in conjunction with both the palate and ventral forebrain, the authors hypothesized that schizophreniapatients might have structural abnormalities of the nasal cavity, which could represent specific markers of embryological dysmorphogenesis underlying schizophrenia. METHOD: A measurement of nasal volume was acquired by acoustic rhinometry for 40 male schizophreniapatients and 24 healthy male comparison subjects. RESULTS: The patients had smaller posterior nasal volumes than the comparison subjects but did not differ in anterior nasal volumes. This difference persisted after covarying for height and smoking history. CONCLUSIONS: The lower observed posterior nasal volume likely reflects a specific developmental craniofacial abnormality. This finding confirms an early disruption in embryological development in males with schizophrenia and may represent a genetic or environmental "first hit" that leaves the individual vulnerable to subsequent pathology.
Authors: David R Roalf; Megan Quarmley; Monica E Calkins; Theodore D Satterthwaite; Kosha Ruparel; Mark A Elliott; Tyler M Moore; Ruben C Gur; Raquel E Gur; Paul J Moberg; Bruce I Turetsky Journal: Schizophr Bull Date: 2017-05-01 Impact factor: 9.306
Authors: Bruce I Turetsky; Charles A Glass; Jaime Abbazia; Christian G Kohler; Raquel E Gur; Paul J Moberg Journal: Schizophr Res Date: 2007-04-11 Impact factor: 4.939
Authors: Curtis K Deutsch; Deborah L Levy; Selya F R Price; J Alexander Bodkin; Lenore Boling; Michael J Coleman; Fred Johnson; Jan Lerbinger; Steven Matthysse; Philip S Holzman Journal: Schizophr Bull Date: 2015-03-20 Impact factor: 9.306
Authors: Sunny X Tang; Paul J Moberg; James J Yi; Andrew S Wiemken; Erich M Dress; Tyler M Moore; Monica E Calkins; Donna M McDonald-McGinn; Elaine H Zackai; Beverly S Emanuel; Ruben C Gur; Raquel E Gur; Bruce I Turetsky Journal: Schizophr Res Date: 2018-07-11 Impact factor: 4.939
Authors: Bruce I Turetsky; Paul J Moberg; Megan Quarmley; Erich Dress; Monica E Calkins; Kosha Ruparel; Karthik Prabhakaran; Raquel E Gur; David R Roalf Journal: Schizophr Res Date: 2017-09-30 Impact factor: 4.939