Literature DB >> 15568780

(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga.

Miriam H Kossuga1, John B MacMillan, Evan W Rogers, Tadeusz F Molinski, Gislene G F Nascimento, Rosana M Rocha, Roberto G S Berlinck.   

Abstract

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/mL and against Candida glabrata with a MIC of 30 microg/mL.

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Year:  2004        PMID： 15568780     DOI： 10.1021/np049782q

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

Review 1.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

2.  D-Glucosamine-derived synthons for assembly of L-threo-sphingoid bases. Total synthesis of rhizochalinin C.

Authors:  Jaeyoung Ko; Tadeusz F Molinski
Journal:  J Org Chem       Date:  2012-12-27       Impact factor: 4.354

3.  Absolute configuration of the alpha,omega-bifunctionalized sphingolipid leucettamol A from Leucetta microrhaphis by deconvoluted exciton coupled CD.

Authors:  Doralyn S Dalisay; Sachiko Tsukamoto; Tadeusz F Molinski
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

Review 4.  Brominated compounds from marine sponges of the genus Aplysina and a compilation of their 13C NMR spectral data.

Authors:  Narlize Silva Lira; Ricardo Carneiro Montes; Josean Fechine Tavares; Marcelo Sobral da Silva; Emidio V L da Cunha; Petronio Filgueiras de Athayde-Filho; Luis Cezar Rodrigues; Celidarque da Silva Dias; Jose Maria Barbosa-Filho
Journal:  Mar Drugs       Date:  2011-11-10       Impact factor: 6.085

5.  Liposomal Circular Dichroism (L-CD) of Arenoyl Derivatives of Sphingolipids. Amplification of Cotton Effects in Ordered Lipid Bilayers.

Authors:  Tadeusz F Molinski; Caroline D Broaddus; Brandon I Morinaka
Journal:  Mar Drugs       Date:  2017-12-20       Impact factor: 5.118

Review 6.  Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.

Authors:  Satheesh Kumar Palanisamy; N M Rajendran; Angela Marino
Journal:  Nat Prod Bioprospect       Date:  2017-01-17

7.  Amino alcohols from the ascidian Pseudodistoma sp.

Authors:  Tae Hyung Won; Minjung You; So-Hyoung Lee; Boon Jo Rho; Dong-Chan Oh; Ki-Bong Oh; Jongheon Shin
Journal:  Mar Drugs       Date:  2014-06-24       Impact factor: 5.118

8.  Bioactive Bromotyrosine Derivatives from the Pacific Marine Sponge Suberea clavata (Pulitzer-Finali, 1982).

Authors:  Céline Moriou; Damien Lacroix; Sylvain Petek; Amr El-Demerdash; Rozenn Trepos; Tinihauarii Mareva Leu; Cristina Florean; Marc Diederich; Claire Hellio; Cécile Debitus; Ali Al-Mourabit
Journal:  Mar Drugs       Date:  2021-03-06       Impact factor: 5.118
  8 in total

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