Literature DB >> 15568765

Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica.

Chihiro Ito1, Masataka Itoigawa, Akiko Furukawa, Takashi Hirano, Tomiyasu Murata, Norio Kaneda, Youichi Hisada, Kazuyo Okuda, Hiroshi Furukawa.   

Abstract

Four new quinolone alkaloids, orixalone A (1), B (2), C (3), and D (4), together with 12 known compounds were isolated from the stems of Orixa japonica. Orixalone A (1) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma and lipopolysaccharide.

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Year:  2004        PMID： 15568765     DOI： 10.1021/np0401462

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Susan L Morris-Natschke; Chen-Fang Wei; Ting-Chen Shen; Hui-Yi Lin; Mei-Hua Hsu; Li-Chen Chou; Yu Zhao; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

2.  Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.

Authors:  Igor V Magedov; Madhuri Manpadi; Marcia A Ogasawara; Adriana S Dhawan; Snezna Rogelj; Severine Van Slambrouck; Wim F A Steelant; Nikolai M Evdokimov; Pavel Y Uglinskii; Eerik M Elias; Erica J Knee; Paul Tongwa; Mikhail Yu Antipin; Alexander Kornienko
Journal:  J Med Chem       Date:  2008-03-25       Impact factor: 7.446

3.  An efficient synthesis of 4H-pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra-n-butylammonium fluoride and their pharmacological screening.

Authors:  Pratibha Prasad; Pratik G Shobhashana; Manish P Patel
Journal:  R Soc Open Sci       Date:  2017-11-29       Impact factor: 2.963

4.  One-pot copper-catalyzed three-component reaction: a modular approach to functionalized 2-quinolones.

Authors:  Ah Reum Kim; Hee Nam Lim
Journal:  RSC Adv       Date:  2020-02-24       Impact factor: 4.036

5.  Synthesis of pyrano[3,2-c]quinolones and furo[3,2-c]quinolones via acid-catalyzed tandem reaction of 4-hydroxy-1-methylquinolin-2(1H)-one and propargylic alcohols.

Authors:  Haiting Yin; Yunjun Wu; Xiaoxia Gu; Zhijun Feng; Meifang Wang; Dexiang Feng; Ming Wang; Ziyang Cheng; Shaoyin Wang
Journal:  RSC Adv       Date:  2022-07-21       Impact factor: 4.036

6.  Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole.

Authors:  Nilesh J Thumar; Manish P Patel
Journal:  Saudi Pharm J       Date:  2011-02-03       Impact factor: 4.330
  6 in total

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