INTRODUCTION: Obesity is associated with risk of breast cancer after menopause. Circulating levels of leptin are high in obesity and leptin stimulates growth of breast cancer cells. MATERIAL AND METHODS: In a case-control study nested within the Northern Sweden Health and Disease Cohort, we measured leptin levels in prediagnostic plasma from 149 postmenopausal women who were diagnosed with breast cancer at a mean time 1.7 years (SD 2.0) after recruitment and among 258 control subjects. RESULTS: No significant association between plasma levels of leptin and breast cancer risk was observed. Odds ratios (ORs) of breast cancer with increasing levels of leptin were 1.00 [referent], 1.01 [95% CI = 0.58-1.84], 0.65 [0.36-1.18], and 0.94 [0.53-1.67], and (p(for trend) = 0.54). Adjustment for smoking, body mass index, and plasma insulin did not affect risk estimates. DISCUSSION: These data do not support the hypothesis that plasma leptin is a risk factor for breast cancer.
INTRODUCTION:Obesity is associated with risk of breast cancer after menopause. Circulating levels of leptin are high in obesity and leptin stimulates growth of breast cancer cells. MATERIAL AND METHODS: In a case-control study nested within the Northern Sweden Health and Disease Cohort, we measured leptin levels in prediagnostic plasma from 149 postmenopausal women who were diagnosed with breast cancer at a mean time 1.7 years (SD 2.0) after recruitment and among 258 control subjects. RESULTS: No significant association between plasma levels of leptin and breast cancer risk was observed. Odds ratios (ORs) of breast cancer with increasing levels of leptin were 1.00 [referent], 1.01 [95% CI = 0.58-1.84], 0.65 [0.36-1.18], and 0.94 [0.53-1.67], and (p(for trend) = 0.54). Adjustment for smoking, body mass index, and plasma insulin did not affect risk estimates. DISCUSSION: These data do not support the hypothesis that plasma leptin is a risk factor for breast cancer.
Authors: Antonio Macciò; Clelia Madeddu; Giulia Gramignano; Carlo Mulas; Carlo Floris; Daniela Massa; Giorgio Astara; Paola Chessa; Giovanni Mantovani Journal: J Mol Med (Berl) Date: 2010-03-26 Impact factor: 4.599
Authors: Stephen D Hursting; John Digiovanni; Andrew J Dannenberg; Maria Azrad; Derek Leroith; Wendy Demark-Wahnefried; Madhuri Kakarala; Angela Brodie; Nathan A Berger Journal: Cancer Prev Res (Phila) Date: 2012-10-03
Authors: Nikki A Ford; Kaylyn L Devlin; Laura M Lashinger; Stephen D Hursting Journal: J Mammary Gland Biol Neoplasia Date: 2013-10-04 Impact factor: 2.673
Authors: Michela Padovani; Jackie A Lavigne; Gadisetti V R Chandramouli; Susan N Perkins; J Carl Barrett; Stephen D Hursting; L Michelle Bennett; David Berrigan Journal: Cancer Prev Res (Phila) Date: 2009-12-01