| Literature DB >> 15567328 |
Bruce J Baum1, Antonis Voutetakis, Jianghua Wang.
Abstract
Directing the local or systemic expression of therapeutic proteins is a potentially important clinical application of gene transfer technology. Gene-based therapeutics theoretically offer many advantages over protein therapeutics. Numerous tissues have been evaluated for this purpose in animal models, most commonly the liver and skeletal muscle. Based on pre-clinical studies, we suggest that salivary glands are a valuable, yet under-appreciated, target tissue for both systemic and upper gastrointestinal tract gene therapeutic applications.Entities:
Mesh：
Year: 2004 PMID： 15567328 DOI： 10.1016/j.molmed.2004.10.003
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951