Literature DB >> 15567323

The promise of siRNAs for the treatment of influenza.

Jack R Bennink1, Tara N Palmore.   

Abstract

Current WHO reports on the Asian avian influenza virus outbreaks are poignant reminders of the potential for the emergence of highly virulent strains of influenza A virus (IAV) and the fact that it remains a scourge on human health. As IAV drifts and shifts its genetic and antigenic composition, it presents an ever-changing challenge for vaccines and antiviral medications. Short-interfering RNAs (siRNAs) are the latest class of potential antiviral therapeutics to be developed. Recent reports using siRNAs in mice suggest that they hold great promise for the prevention and treatment of IAV infections.

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Year:  2004        PMID： 15567323     DOI： 10.1016/j.molmed.2004.10.004

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  8 in total

1.  Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells.

Authors:  Miao Jiang; Pamela Österlund; Veera Westenius; Deyin Guo; Minna M Poranen; Dennis H Bamford; Ilkka Julkunen
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

2.  Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene.

Authors:  Xiaoyuan Kong; Weidong Zhang; Richard F Lockey; Alexander Auais; Giovanni Piedimonte; Shyam S Mohapatra
Journal:  Genet Vaccines Ther       Date:  2007-02-01

3.  Inhibiting avian influenza virus shedding using a novel RNAi antiviral vector technology: proof of concept in an avian cell model.

Authors:  Lyndsey M Linke; Jeffrey Wilusz; Kristy L Pabilonia; Johannes Fruehauf; Roberta Magnuson; Francisco Olea-Popelka; Joni Triantis; Gabriele Landolt; Mo Salman
Journal:  AMB Express       Date:  2016-02-24       Impact factor: 3.298

Review 4.  RNA interference for antiviral therapy.

Authors:  Mali Ketzinel-Gilad; Yosef Shaul; Eithan Galun
Journal:  J Gene Med       Date:  2006-08       Impact factor: 4.565

5.  Intracranial administration of P gene siRNA protects mice from lethal Chandipura virus encephalitis.

Authors:  Satyendra Kumar; Vidya A Arankalle
Journal:  PLoS One       Date:  2010-01-07       Impact factor: 3.240

Review 6.  Insight into alternative approaches for control of avian influenza in poultry, with emphasis on highly pathogenic H5N1.

Authors:  E M Abdelwhab; Hafez M Hafez
Journal:  Viruses       Date:  2012-11-19       Impact factor: 5.048

7.  A single siRNA suppresses fatal encephalitis induced by two different flaviviruses.

Authors:  Priti Kumar; Sang Kyung Lee; Premlata Shankar; N Manjunath
Journal:  PLoS Med       Date:  2006-02-14       Impact factor: 11.069

Review 8.  Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses.

Authors:  Kevin B Spurgers; C Matthew Sharkey; Kelly L Warfield; Sina Bavari
Journal:  Antiviral Res       Date:  2008-01-14       Impact factor: 5.970
  8 in total

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