| Literature DB >> 15567291 |
Marina Zacchigna1, Gabriella Di Luca, Francesca Cateni, Venerando Maurich.
Abstract
One of the most used and useful polymers, poly(ethylene glycol) (PEG) was used as a carrier for warfarin. The drug-polymer conjugate was freely water soluble at room temperature. The hydrolytic stability of the PEG-warfarin was investigated at physiological pH and confirmed the stability of the conjugate. In vivo release studies demonstrated a good release of parent drug, without the initial high plasma level of warfarin.Entities:
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Year: 2004 PMID： 15567291 DOI： 10.1016/j.ejps.2004.09.001
Source DB: PubMed Journal: Eur J Pharm Sci ISSN： 0928-0987 Impact factor: 4.384