| Literature DB >> 15567073 |
Silvana Galderisi1, Mario Maj, Brian Kirkpatrick, Paola Piccardi, Armida Mucci, Giordano Invernizzi, Alessandro Rossi, Stefano Pini, Antonio Vita, Paolo Cassano, Paolo Stratta, Giovanni Severino, Maria Del Zompo.
Abstract
In a multicenter study involving 217 subjects of European ancestry [106 patients with schizophrenia and 111 healthy subjects], we tested the hypothesis that the catechol-O-methyl transferase (COMT) Val(158)Met and/or the brain-derived neurotrophic factor (BDNF) C(270)T gene polymorphisms are associated with schizophrenia. The COMT and BDNF genotype and their allele distribution did not differ between patients with schizophrenia and healthy comparison subjects. These results do not support the hypothesis that the COMT Val(158)Met or BDNF C(270)T gene polymorphisms are associated with liability to schizophrenia.Entities:
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Year: 2005 PMID： 15567073 DOI： 10.1016/j.schres.2004.06.017
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939