Literature DB >> 15566289

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Veerle Vanheusden1, Hélène Munier-Lehmann, Matheus Froeyen, Roger Busson, Jef Rozenski, Piet Herdewijn, Serge Van Calenbergh.   

Abstract

Thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for selectively blocking bacterial DNA synthesis. Hereby, we report on the discovery of a novel class of bicyclic nucleosides (10 and 11) and one dinucleoside (12), belonging to the most selective inhibitors of TMPKmt discovered so far.

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Year:  2004        PMID： 15566289     DOI： 10.1021/jm040847w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  10 in total

1.  3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents.

Authors:  Carolina Horta Andrade; Kerly F M Pasqualoto; Elizabeth I Ferreira; Anton J Hopfinger
Journal:  J Comput Aided Mol Des       Date:  2010-03-10       Impact factor: 3.686

2.  Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: fragment-based QSAR and QM/MM docking studies.

Authors:  Renata V Bueno; Ney R Toledo; Bruno J Neves; Rodolpho C Braga; Carolina H Andrade
Journal:  J Mol Model       Date:  2012-07-31       Impact factor: 1.810

Review 3.  Protein targets for structure-based anti-Mycobacterium tuberculosis drug discovery.

Authors:  Zhiyong Lou; Xiaoxue Zhang
Journal:  Protein Cell       Date:  2010-06-04       Impact factor: 14.870

4.  Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Authors:  Jun Yong Choi; Mark S Plummer; Jeremy Starr; Charlene R Desbonnet; Holly Soutter; Jeanne Chang; J Richard Miller; Keith Dillman; Alita A Miller; William R Roush
Journal:  J Med Chem       Date:  2012-01-13       Impact factor: 7.446

5.  Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Authors:  Vladimir Frecer; Pierfausto Seneci; Stanislav Miertus
Journal:  J Comput Aided Mol Des       Date:  2010-11-17       Impact factor: 3.686

6.  Structure-based in-silico rational design of a selective peptide inhibitor for thymidine monophosphate kinase of mycobacterium tuberculosis.

Authors:  Manoj Kumar; Sujata Sharma; Alagiri Srinivasan; Tej P Singh; Punit Kaur
Journal:  J Mol Model       Date:  2010-08-11       Impact factor: 1.810

7.  Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking.

Authors:  Hatice Yıldırım; Mahmut Yıldız; Nilüfer Bayrak; Emel Mataracı-Kara; Mohamed Osman Radwan; Ayse Tarbin Jannuzzi; Masami Otsuka; Mikako Fujita; Amaç Fatih TuYuN
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-10

8.  Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.

Authors:  Gilles Labesse; Khaled Benkali; Isabelle Salard-Arnaud; Anne-Marie Gilles; Hélène Munier-Lehmann
Journal:  Nucleic Acids Res       Date:  2010-12-10       Impact factor: 16.971

Review 9.  Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors.

Authors:  Liudmila A Alexandrova; Anastasia L Khandazhinskaya; Elena S Matyugina; Dmitriy A Makarov; Sergey N Kochetkov
Journal:  Microorganisms       Date:  2022-06-27

10.  Chemotherapeutic interventions against tuberculosis.

Authors:  Neeraj Shakya; Gaurav Garg; Babita Agrawal; Rakesh Kumar
Journal:  Pharmaceuticals (Basel)       Date:  2012-06-28
  10 in total

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