| Literature DB >> 15564722 |
R John Looney1, Jennifer Anolik, Iñaki Sanz.
Abstract
Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organ systems and characterized by anti-nuclear antibodies. While T cells and dendritic cells may play major roles in SLE, several lines of evidence strongly suggest a central role for B cells. This article will review the role of B cells in human SLE as well as the currently available data on the treatment of SLE by depleting B cells with anti-CD20 (rituximab).Entities:
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Year: 2005 PMID： 15564722 DOI： 10.1159/000082104
Source DB: PubMed Journal: Curr Dir Autoimmun ISSN： 1422-2132