OBJECTIVE: To elucidate the pathogenesis of leuko-araiosis in patients with Alzheimer's disease by utilizing CT densitometry of the brain and measurements of local perfusion in order to quantify the extent of leuko-araiosis and local hypoperfusion compared with similar measurements made among age-matched normal volunteers. DESIGN: Cross-sectional case-control study. SETTING: Out-patient visits to a specialized laboratory located in a large hospital facility. PATIENTS: Eighteen elderly patients with probable dementia of Alzheimer type (DAT, aged 71.8 +/- 5.1 years) and 17 neurologically and cognitively normal, age-matched volunteers (aged 68.2 +/- 9.6 years) were admitted to the study according to established criteria. INTERVENTION: None MAIN OUTCOME MEASURES: Cerebral blood flow (mL/100 g brain/min) estimated by the xenon inhalation CT-CBF method correlated with volume percentage ratio (%) measured by CT densitometry for leuko-araiosis, compared to normal white and gray matter. RESULTS: Perfusion values for frontal and occipital white matter as well as frontal, parietal, temporal, and occipital cortex were all decreased in DAT patients. Ratios for leuko-araiosis to total brain tissue volumes were greater among patients with DAT compared with age-matched normal volunteers. White matter perfusion in zones of leuko-araiosis was decreased to a similar degree in both DAT and elderly normal volunteers. CONCLUSIONS: Perfusion is reduced to the same degree in regions of leuko-araiosis in elderly normals as in DAT patients, but the extent of leuko-araiosis is greater among DAT patients and presumably contributes to cognitive impairments.
OBJECTIVE: To elucidate the pathogenesis of leuko-araiosis in patients with Alzheimer's disease by utilizing CT densitometry of the brain and measurements of local perfusion in order to quantify the extent of leuko-araiosis and local hypoperfusion compared with similar measurements made among age-matched normal volunteers. DESIGN: Cross-sectional case-control study. SETTING: Out-patient visits to a specialized laboratory located in a large hospital facility. PATIENTS: Eighteen elderly patients with probable dementia of Alzheimer type (DAT, aged 71.8 +/- 5.1 years) and 17 neurologically and cognitively normal, age-matched volunteers (aged 68.2 +/- 9.6 years) were admitted to the study according to established criteria. INTERVENTION: None MAIN OUTCOME MEASURES: Cerebral blood flow (mL/100 g brain/min) estimated by the xenon inhalation CT-CBF method correlated with volume percentage ratio (%) measured by CT densitometry for leuko-araiosis, compared to normal white and gray matter. RESULTS: Perfusion values for frontal and occipital white matter as well as frontal, parietal, temporal, and occipital cortex were all decreased in DAT patients. Ratios for leuko-araiosis to total brain tissue volumes were greater among patients with DAT compared with age-matched normal volunteers. White matter perfusion in zones of leuko-araiosis was decreased to a similar degree in both DAT and elderly normal volunteers. CONCLUSIONS: Perfusion is reduced to the same degree in regions of leuko-araiosis in elderly normals as in DAT patients, but the extent of leuko-araiosis is greater among DAT patients and presumably contributes to cognitive impairments.
Authors: Eduardo M Castaño; Chera L Maarouf; Terence Wu; Maria Celeste Leal; Charisse M Whiteside; Lih-Fen Lue; Tyler A Kokjohn; Marwan N Sabbagh; Thomas G Beach; Alex E Roher Journal: Neurochem Int Date: 2012-12-08 Impact factor: 3.921
Authors: A F Leuchter; J J Dunkin; R B Lufkin; Y Anzai; I A Cook; T F Newton Journal: J Neurol Neurosurg Psychiatry Date: 1994-11 Impact factor: 10.154
Authors: Alex E Roher; Chera L Maarouf; Michael Malek-Ahmadi; Jeffrey Wilson; Tyler A Kokjohn; Ian D Daugs; Charisse M Whiteside; Walter M Kalback; Mimi P Macias; Sandra A Jacobson; Marwan N Sabbagh; Bernardino Ghetti; Thomas G Beach Journal: Am J Neurodegener Dis Date: 2013-09-18
Authors: S MacKay; F Ezekiel; V Di Sclafani; D J Meyerhoff; J Gerson; D Norman; G Fein; M W Weiner Journal: Radiology Date: 1996-02 Impact factor: 11.105