BACKGROUND: The expansion of indications for implantation of cardioverter-defibrillators (ICD) has enhanced the need for risk stratification of patients post myocardial infarction (MI), while the improved treatment of acute MI has decreased mortality and diminished the prognostic power of traditional risk variables. HYPOTHESIS: Increased heterogeneity of ventricular repolarization quantified by TCRT (total cosine R-to-T, angular difference between spatial QRS and T loops, decreased with increase in repolarization heterogeneity) is an independent predictor of mortality in patients post MI. METHODS: Left ventricular ejection fraction (EF), QRS duration on signal-averaged ECG, number of ventricular ectopic beats (VE)/h, heart rate variability (HRV) triangular index, heart rate turbulence slope on 24-h Holter recording, and TCRT were analyzed in 334 survivors of acute MI followed up for 41 +/- 20 months. RESULTS: In multivariate analysis, EF < 35% (relative risk [RR] 2.3, 95% confidence interval [CI] 1.1-4.7, p = 0.023), VE > 10/h (RR 2.2, CI 1.0-4.6, p = 0.044), HRV < 20 U (RR 2.2, CI 1.1-4.5, p = 0.032), and TCRT < -0.896 (RR 4.3, CI 2.2-8.5, p = 0.00001) were independent predictors of cardiac mortality (11%). Independent predictors of arrhythmic mortality (5%) were VE, HRV, and TCRT (RR 5.8, CI 2.1-15.6, p = 0.0004). Cardiac and arrhythmic mortality of patients with both EF <35% and TCRT < -0.896 were >60 and >30%, respectively, compared with 17 and 7% in those with only EF <35% or TCRT < -0.896. CONCLUSION: Decreased TCRT, which reflects increased repolarization heterogeneity, is a strong and independent predictor of cardiac and arrhythmic death in patients post MI.
BACKGROUND: The expansion of indications for implantation of cardioverter-defibrillators (ICD) has enhanced the need for risk stratification of patients post myocardial infarction (MI), while the improved treatment of acute MI has decreased mortality and diminished the prognostic power of traditional risk variables. HYPOTHESIS: Increased heterogeneity of ventricular repolarization quantified by TCRT (total cosine R-to-T, angular difference between spatial QRS and T loops, decreased with increase in repolarization heterogeneity) is an independent predictor of mortality in patients post MI. METHODS: Left ventricular ejection fraction (EF), QRS duration on signal-averaged ECG, number of ventricular ectopic beats (VE)/h, heart rate variability (HRV) triangular index, heart rate turbulence slope on 24-h Holter recording, and TCRT were analyzed in 334 survivors of acute MI followed up for 41 +/- 20 months. RESULTS: In multivariate analysis, EF < 35% (relative risk [RR] 2.3, 95% confidence interval [CI] 1.1-4.7, p = 0.023), VE > 10/h (RR 2.2, CI 1.0-4.6, p = 0.044), HRV < 20 U (RR 2.2, CI 1.1-4.5, p = 0.032), and TCRT < -0.896 (RR 4.3, CI 2.2-8.5, p = 0.00001) were independent predictors of cardiac mortality (11%). Independent predictors of arrhythmic mortality (5%) were VE, HRV, and TCRT (RR 5.8, CI 2.1-15.6, p = 0.0004). Cardiac and arrhythmic mortality of patients with both EF <35% and TCRT < -0.896 were >60 and >30%, respectively, compared with 17 and 7% in those with only EF <35% or TCRT < -0.896. CONCLUSION: Decreased TCRT, which reflects increased repolarization heterogeneity, is a strong and independent predictor of cardiac and arrhythmic death in patients post MI.
Authors: Gary Tse; Mengqi Gong; Cheuk Wai Wong; Cynthia Chan; Stamatis Georgopoulos; Yat Sun Chan; Bryan P Yan; Guangping Li; Paula Whittaker; Ana Ciobanu; Sadeq Ali-Hasan-Al-Saegh; Sunny H Wong; William K K Wu; George Bazoukis; Konstantinos Lampropoulos; Wing Tak Wong; Lap Ah Tse; Adrian M Baranchuk; Konstantinos P Letsas; Tong Liu Journal: Ann Noninvasive Electrocardiol Date: 2017-09-12 Impact factor: 1.468
Authors: M L Koivikko; M Karsikas; P I Salmela; J S Tapanainen; A Ruokonen; T Seppänen; H V Huikuri; J S Perkiömäki Journal: Diabetologia Date: 2007-12-19 Impact factor: 10.122
Authors: Eeva H Linna; Juha S Perkiömäki; Mari Karsikas; Tapio Seppänen; Markku Savolainen; Y Antero Kesäniemi; Timo Mäkikallio; Heikki V Huikuri Journal: Ann Noninvasive Electrocardiol Date: 2006-01 Impact factor: 1.468