BACKGROUND: Pressurized metered-dose inhalers (pMDIs) are often poorly used, but little information is available concerning use of the newer dry powder inhalers (DPIs). OBJECTIVE: To estimate the inhalation technique and variables associated with the misuse of pMDIs and newer DPIs in clinical practice. METHODS: A multicenter, observational survey was used to evaluate the inhalation technique in 1,404 experienced outpatients aged 15 to 88 years affected mostly by asthma (47%) and chronic obstructive pulmonary disease (39%). A total of 1,056 patients were using pMDIs, 190 in conjunction with a large volume spacer (LVS); regarding DPIs, 230 patients were using the Aerolizer Inhaler, 524 were using the Turbuhaler, and 475 were using the Diskus. In each center, a trained observer recorded patients' inhalation techniques for each inhaler used against a standardized step-by-step checklist. RESULTS: Twenty-four percent and 3% of patients used pMDIs poorly, alone or with an add-on LVS, respectively. Failure to correctly perform essential steps for reliable lung delivery with the Aerolizer Inhaler, Turbuhaler, and Diskus was found in 17%, 23%, and 24% of patients, respectively. There was no difference in most variables correlated with poor inhalation between patients using pMDIs and those using DPIs. CONCLUSIONS: The use of DPIs is associated with a similar percentage of inadequate inhalation technique as the use of pMDIs in clinical practice. The addition of an LVS to a pMDI and education from health care personnel, rather than simply changing inhalers, represent the best strategies for minimizing poor inhalation technique.
BACKGROUND: Pressurized metered-dose inhalers (pMDIs) are often poorly used, but little information is available concerning use of the newer dry powder inhalers (DPIs). OBJECTIVE: To estimate the inhalation technique and variables associated with the misuse of pMDIs and newer DPIs in clinical practice. METHODS: A multicenter, observational survey was used to evaluate the inhalation technique in 1,404 experienced outpatients aged 15 to 88 years affected mostly by asthma (47%) and chronic obstructive pulmonary disease (39%). A total of 1,056 patients were using pMDIs, 190 in conjunction with a large volume spacer (LVS); regarding DPIs, 230 patients were using the Aerolizer Inhaler, 524 were using the Turbuhaler, and 475 were using the Diskus. In each center, a trained observer recorded patients' inhalation techniques for each inhaler used against a standardized step-by-step checklist. RESULTS: Twenty-four percent and 3% of patients used pMDIs poorly, alone or with an add-on LVS, respectively. Failure to correctly perform essential steps for reliable lung delivery with the Aerolizer Inhaler, Turbuhaler, and Diskus was found in 17%, 23%, and 24% of patients, respectively. There was no difference in most variables correlated with poor inhalation between patients using pMDIs and those using DPIs. CONCLUSIONS: The use of DPIs is associated with a similar percentage of inadequate inhalation technique as the use of pMDIs in clinical practice. The addition of an LVS to a pMDI and education from health care personnel, rather than simply changing inhalers, represent the best strategies for minimizing poor inhalation technique.
Authors: Katie Kiser; Daniel Jonas; Zachary Warner; Kelli Scanlon; Betsy Bryant Shilliday; Darren A DeWalt Journal: J Gen Intern Med Date: 2011-09-21 Impact factor: 5.128
Authors: Jansen N Seheult; Peter O'Connell; Kee Chun Tee; Tariq Bholah; Hasan Al Bannai; Imran Sulaiman; Elaine MacHale; Shona D'Arcy; Martin S Holmes; David Bergin; Emer Reeves; Richard B Reilly; Gloria Crispino-O'Connell; Carsten Ehrhardt; Anne Marie Healy; Richard W Costello Journal: Pharm Res Date: 2014-05-28 Impact factor: 4.200
Authors: Thomas Voshaar; Monica Spinola; Patrick Linnane; Alice Campanini; Daniel Lock; Anthony Lafratta; Mario Scuri; Barbara Ronca; Andrea S Melani Journal: J Aerosol Med Pulm Drug Deliv Date: 2013-12-03 Impact factor: 2.849