| Literature DB >> 15562820 |
Shoshana Yakar1, Patricia Pennisi, Hong Zhao, Yang Zhang, Derek LeRoith.
Abstract
Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.Entities:
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Year: 2004 PMID： 15562820
Source DB: PubMed Journal: Novartis Found Symp ISSN： 1528-2511