| Literature DB >> 15562414 |
Philipp Ströbel1, Andreas Rosenwald, Niklas Beyersdorf, Thomas Kerkau, Olaf Elert, Astrid Murumägi, Niko Sillanpää, Pärt Peterson, Vera Hummel, Peter Rieckmann, Christof Burek, Berthold Schalke, Wilfred Nix, Reinhard Kiefer, Hans Konrad Müller-Hermelink, Alexander Marx.
Abstract
Myasthenia gravis (MG) is the prime autoimmune manifestation of thymomas. We investigated the generation of T cells with a regulatory phenotype (T(R)) in thymomas with and without associated MG. In patients with MG(+) thymomas, maturation and export of T(R) cells but not of other T-cell subsets was significantly reduced. We conclude that imbalance between effector and regulatory T cells in thymomas may be involved in modulation of onset and/or severity of MG.Entities:
Mesh：
Year: 2004 PMID： 15562414 DOI： 10.1002/ana.20340
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422