OBJECTIVE: To review the safety and efficacy of selective serotonin-reuptake inhibitors (SSRIs) for the treatment of depression in adults with HIV. DATA SOURCES: We searched Pre-MEDLINE and MEDLINE (1966-May 2004) using terms including generic names of antidepressants and antiretrovirals, depression, HIV, and acquired immunodeficiency syndrome. All English-language articles were included in this review. DATA SYNTHESIS: SSRIs may be effective and better tolerated than tricyclic antidepressants in HIV-positive adults. SSRIs did not appear to affect CD4+ cell counts. CONCLUSIONS: Controlled trials comparing SSRIs are lacking; thus, it is difficult to determine whether one SSRI is more efficacious than another. It appears that most SSRIs may be used in HIV-positive adults. If drug-drug interactions are a concern, sertraline, citalopram, and possibly escitalopram may be considered.
OBJECTIVE: To review the safety and efficacy of selective serotonin-reuptake inhibitors (SSRIs) for the treatment of depression in adults with HIV. DATA SOURCES: We searched Pre-MEDLINE and MEDLINE (1966-May 2004) using terms including generic names of antidepressants and antiretrovirals, depression, HIV, and acquired immunodeficiency syndrome. All English-language articles were included in this review. DATA SYNTHESIS: SSRIs may be effective and better tolerated than tricyclic antidepressants in HIV-positive adults. SSRIs did not appear to affect CD4+ cell counts. CONCLUSIONS: Controlled trials comparing SSRIs are lacking; thus, it is difficult to determine whether one SSRI is more efficacious than another. It appears that most SSRIs may be used in HIV-positive adults. If drug-drug interactions are a concern, sertraline, citalopram, and possibly escitalopram may be considered.
Authors: Larry K Brown; Miriam Chernoff; Betsy D Kennard; Graham J Emslie; Kathryn Lypen; Sarah Buisson; Adriana Weinberg; Laura B Whiteley; Shirley Traite; Chelsea Krotje; Lauren Harriff; Ellen Townley; Amber Bunch; Murli Purswani; Ray Shaw; Stephen A Spector; Allison Agwu; David E Shapiro Journal: J Acquir Immune Defic Syndr Date: 2021-12-15 Impact factor: 3.771
Authors: Dima A Hammoud; Christopher J Endres; Edward Hammond; Ovsev Uzuner; Amanda Brown; Avindra Nath; Adam I Kaplin; Martin G Pomper Journal: Neuroimage Date: 2009-10-21 Impact factor: 6.556
Authors: Larry K Brown; Betsy D Kennard; Graham J Emslie; Taryn L Mayes; Laura B Whiteley; James Bethel; Jiahong Xu; Sarah Thornton; Mary R Tanney; Linda A Hawkins; Patricia A Garvie; Geetha A Subramaniam; Carol J Worrell; Laura W Stoff Journal: J Acquir Immune Defic Syndr Date: 2016-01-01 Impact factor: 3.731
Authors: Michael R Keegan; Seetharamaiah Chittiprol; Scott L Letendre; Alan Winston; Dietmar Fuchs; Adriano Boasso; Jennifer Iudicello; Ronald J Ellis Journal: Int J Tryptophan Res Date: 2016-10-26