Literature DB >> 15561821

TEM-121, a novel complex mutant of TEM-type beta-lactamase from Enterobacter aerogenes.

Laurent Poirel1, Hedi Mammeri, Patrice Nordmann.   

Abstract

Enterobacter aerogenes clinical isolate LOR was resistant to penicillins and ceftazidime but susceptible to cefuroxime, cephalothin, cefoxitin, cefotaxime, ceftriaxone, and cefepime. PCR and cloning experiments from this strain identified a novel TEM-type beta-lactamase (TEM-121) differing by five amino acid substitutions from beta-lactamase TEM-2 (Glu104Lys, Arg164Ser, Ala237Thr, Glu240Lys, and Arg244Ser) and by only one amino acid change from the extended-spectrum beta-lactamase (ESBL) TEM-24 (Arg244Ser), with the last substitution also being identified in the inhibitor-resistant beta-lactamase IRT-2. Kinetic parameters indicated that TEM-121 hydrolyzed ceftazidime and aztreonam (like TEM-24) and was inhibited weakly by clavulanic acid and strongly by tazobactam. Thus, TEM-121 is a novel complex mutant TEM beta-lactamase (CMT-4) combining the kinetic properties of an ESBL and an inhibitor-resistant TEM enzyme.

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Year:  2004        PMID： 15561821      PMCID： PMC529203          DOI： 10.1128/AAC.48.12.4528-4531.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Nucleotide sequence of the chromosomal ampC gene of Enterobacter aerogenes.

Authors:  K E Preston; C C Radomski; R A Venezia
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

2.  TEM-89 beta-lactamase produced by a Proteus mirabilis clinical isolate: new complex mutant (CMT 3) with mutations in both TEM-59 (IRT-17) and TEM-3.

Authors:  C Neuwirth; S Madec; E Siebor; A Pechinot; J M Duez; M Pruneaux; M Fouchereau-Peron; A Kazmierczak; R Labia
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

3.  Catalytic and structural properties of IRT-21 beta-lactamase (TEM-77) from a co-amoxiclav-resistant Proteus mirabilis isolate.

Authors:  H Mammeri; L Gilly; G Laurans; G Vedel; F Eb; G Paul
Journal:  FEMS Microbiol Lett       Date:  2001-12-18       Impact factor: 2.742

4.  TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511.

Authors:  Rodrigo Alonso; Guy Gerbaud; Marc Galimand; Patrice Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

5.  Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytoca.

Authors:  H Bermudes; F Jude; E B Chaibi; C Arpin; C Bebear; R Labia; C Quentin
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

6.  Essential structure of E. coli promoter: effect of spacer length between the two consensus sequences on promoter function.

Authors:  T Aoyama; M Takanami; E Ohtsuka; Y Taniyama; R Marumoto; H Sato; M Ikehara
Journal:  Nucleic Acids Res       Date:  1983-09-10       Impact factor: 16.971

7.  Coexistence of SHV-4- and TEM-24-producing Enterobacter aerogenes strains before a large outbreak of TEM-24-producing strains in a French hospital.

Authors:  H Mammeri; G Laurans; M Eveillard; S Castelain; F Eb
Journal:  J Clin Microbiol       Date:  2001-06       Impact factor: 5.948

8.  A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.

Authors:  J Fiett; A Pałucha; B Miaczyńska; M Stankiewicz; H Przondo-Mordarska; W Hryniewicz; M Gniadkowski
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

9.  TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone.

Authors:  P Dumarche; C De Champs; D Sirot; C Chanal; R Bonnet; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  2002-04       Impact factor: 5.191

10.  Outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital.

Authors:  Laurent Poirel; Olivier Menuteau; Nathalie Agoli; Christian Cattoen; Patrice Nordmann
Journal:  J Clin Microbiol       Date:  2003-08       Impact factor: 5.948
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  14 in total

1.  Virulence factors and TEM-type β-lactamases produced by two isolates of an epidemic Klebsiella pneumoniae strain.

Authors:  Frédéric Robin; Claire Hennequin; Marek Gniadkowski; Racha Beyrouthy; Joanna Empel; Lucie Gibold; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2011-11-21       Impact factor: 5.191

2.  CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection.

Authors:  Frédéric Robin; Julien Delmas; Maryse Archambaud; Cédric Schweitzer; Catherine Chanal; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

3.  Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient.

Authors:  Frédéric Robin; Julien Delmas; Cédric Schweitzer; Olivier Tournilhac; Olivier Lesens; Catherine Chanal; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2007-01-12       Impact factor: 5.191

4.  TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.

Authors:  Frédéric Robin; Julien Delmas; Amélie Brebion; Damien Dubois; Jean-Michel Constantin; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2007-08-20       Impact factor: 5.191

5.  Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii.

Authors:  Pauline D Mugnier; Laurent Poirel; Patrice Nordmann
Journal:  J Bacteriol       Date:  2009-01-09       Impact factor: 3.490

6.  TEM-187, a new extended-spectrum β-lactamase with weak activity in a Proteus mirabilis clinical strain.

Authors:  Stéphane Corvec; Racha Beyrouthy; Lise Crémet; Guillaume Ghislain Aubin; Frédéric Robin; Richard Bonnet; Alain Reynaud
Journal:  Antimicrob Agents Chemother       Date:  2013-03-11       Impact factor: 5.191

7.  The MAST® D68C test: an interesting tool for detecting extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae.

Authors:  C Nourrisson; R N Tan; C Hennequin; L Gibold; R Bonnet; F Robin
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-01-14       Impact factor: 3.267

8.  TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5).

Authors:  F Robin; J Delmas; C Chanal; D Sirot; J Sirot; R Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

9.  International spread and persistence of TEM-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an IncA/C2 plasmid containing Tn1696::Tn1 and IS5075-Tn21.

Authors:  Angela Novais; Fernando Baquero; Elisabete Machado; Rafael Cantón; Luísa Peixe; Teresa M Coque
Journal:  Antimicrob Agents Chemother       Date:  2009-12-07       Impact factor: 5.191

Review 10.  Cefepime: a reappraisal in an era of increasing antimicrobial resistance.

Authors:  Andrea Endimiani; Federico Perez; Robert A Bonomo
Journal:  Expert Rev Anti Infect Ther       Date:  2008-12       Impact factor: 5.091
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